Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A 45-year-old Japanese woman had sudden-onset subarachnoid hemorrhage and subsequently developed recurrent intracerebral hemorrhages and multiple infarctions in the left and right cerebral hemispheres, respectively. Angiotensin-converting enzyme (ACE) levels in the cerebrospinal fluid (CSF) were elevated, and a pathological examination of brain biopsy samples demonstrated multinucleated giant cell infiltration and epithelial granuloma formation in thickened pial vessel walls. After treatment with intravascular methylprednisolone 1,000 mg for 3 days, followed by oral prednisolone, she had no recurrence of cerebrovascular events. Although systemic involvement was lacking, isolated neurosarcoidosis was diagnosed based on increased ACE levels in the CSF and pathological findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2169/internalmedicine.5679-25 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Health literacy, multimorbidity and its effect on mental health in South African adults: a repeated cross-sectional nationally representative panel study.
Front Public Health
September 2025
SAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Objective And Methods: Health literacy is a key determinant of physical and mental health outcomes, particularly in low- and middle-income settings like South Africa, where multimorbidity is increasingly common. Limited health literacy may hinder effective management of multiple chronic conditions and worsen mental health. Using repeated cross-sectional nationally representative data, this study examined the relationship between health literacy and multimorbidity, with a specific focus on mental health among South African adults (18 years and older).
View Article and Find Full Text PDFRational module substitution strategy to enhance ACE-inhibitory peptide activity.
Food Chem
August 2025
College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China. Electronic address:
Food-derived angiotensin-converting enzyme (ACE)-inhibitory peptide plays key roles in hypertension prevention, however, their activity is dependent on specific sequence composition. This study aims to enhance peptide activity using a module substitution strategy. Molecular docking and activity assays identified MF as a low- and FP as a high-contribution dipeptide module within MFPWP.
View Article and Find Full Text PDFIL10 (-1082 G>A, rs1800896) gene polymorphisms are associated with oxidative stress in sickle cell disease patients in Uganda.
Biol Res
September 2025
Department of Biochemistry and Systems Biology, School of Biosciences, College of Natural Sciences, Makerere University, P.O. Box 7062, Kampala, Uganda.
Background: Sickle cell disease (SCD) is characterised by chronic oxidative stress. However, there is limited information on how polymorphisms in cytokine genes influence oxidative stress in SCD patients. The study aimed to determine the effect of Interleukin gene (IL-10) and Tumor Necrosis Factor (TNF) polymorphisms on oxidative stress and cytokine levels in SCD patients from Mulago hospital.
View Article and Find Full Text PDF3D Spatial Learning for Adsorption Energy Prediction in Multi-Temporal Solution Systems: The MTSS Data Set and a GCN-Based Network.
J Chem Inf Model
September 2025
Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100864, China.
Existing methods for adsorption energy prediction primarily focus on individual molecules or static molecular pairs, lacking the capabilities to model the diverse spatial configurations found in complex solution systems. While traditional data sets are static, dynamic systems explore a vast conformational space over time. This paper introduces the Multi-Temporal Solution System (MTSS) data set containing 500,000 temporally resolved configurations (3D atomic coordinates + adsorption energy labels) across five solvents.
View Article and Find Full Text PDFAssessment of adipokine and inflammation biomarkers with cancer risk among Chinese men: A prospective cohort study.
Cancer Epidemiol Biomarkers Prev
September 2025
Vanderbilt University Medical Center, Nashville, TN, United States.
Background: Obesity and chronic inflammation are associated with cancer risk. We investigated the association between adipokines, inflammation markers, and cancer risk among Chinese men.
Methods: Using pre-diagnosis fasting plasma samples from 4,051 (6.