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Cancer nanotechnologies have the potential to revolutionize cancer diagnosis and treatment; however, their complexity poses challenges to data analysis and knowledge sharing. caNanoLab, a dedicated cancer nanotechnology data-sharing portal, has emerged as a valuable resource for researchers in this field. However, to fully utilize the wealth of data available in caNanoLab, there is a need for real-time descriptive statistical presentation and an optimized user experience. Herein, we provide an overview of cancer nanotechnologies and federally funded efforts to create data repositories, aiming to improve information flow and data sharing among researchers in the cancer nanotechnology field. We use caNanoLab as a case study to analyze the challenges in this area and highlight how caNanoLab addresses them. We also identify gaps and explore the potential of Large Language Models (LLMs) to improve user experience. A more detailed analysis of LLM and their applications to caNanoLab is provided in the second part of this review. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
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http://dx.doi.org/10.1002/wnan.70030 | DOI Listing |
Cell Rep Med
August 2025
Center for Biomedical-photonics and Molecular Imaging, Advanced Diagnostic-Therapy Technology and Equipment Key Laboratory of Higher Education Institutions in Shaanxi Province, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China; Engineering Research Center of Mole
Rapid identification and accurate diagnosis are critical for individuals with acute leukemia (AL). Here, we propose a combined deep learning and surface-enhanced Raman scattering (DL-SERS) classification strategy to achieve rapid and sensitive identification of AL with various subtypes and genetic abnormalities. More than 390 of cerebrospinal fluid (CSF) samples are collected as targets, encompassing healthy control, AL patients, and individuals with other diseases.
View Article and Find Full Text PDFInorg Chem
September 2025
Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
This study focuses on designing and developing a novel three-dimensional porphyrinic covalent organic framework (3D-Por-COF) to enhance anticancer sono-photodynamic therapy (SPDT). Leveraging the unique structural advantages of 3D COFs, this work addresses the limitations of traditional 2D-Por-COFs, particularly regarding reactive oxygen species (ROS) production and therapeutic efficacy. The newly developed 3D-Por-COF demonstrated significantly higher ROS generation under combined sonodynamic and photodynamic conditions, leading to an improved therapeutic effect against prostate cancer cells.
View Article and Find Full Text PDFCancer Pathog Ther
September 2025
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, India.
Breast cancer remains one of the leading causes of cancer-related morbidity and mortality among women worldwide, necessitating the development of novel therapeutic strategies. Phytoconstituents, naturally plant-derived bioactive compounds, have emerged as promising agents for breast cancer therapy due to their multifaceted mechanisms of action. This review examines the role of phytoconstituents in inducing apoptosis, inhibiting breast cancer cell proliferation, and suppressing metastasis.
View Article and Find Full Text PDFAdv Pharm Bull
July 2025
Cell Therapy Center, The University of Jordan, 11942, Amman, Jordan.
Purpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develop safer and more efficient cancer treatment methods.
View Article and Find Full Text PDFFood Res Int
November 2025
Dairy Research Department, Food Technology Research Institute, ARC, Giza 12619, Egypt.
Domiati cheese, one of the most popular soft white cheeses, is particularly susceptible to microbial deterioration due to its high moisture content and low salt concentration. This study assesses the effectiveness of a new edible coating made from carboxymethyl chitosan nanoparticles loaded with pomegranate peel extract (CCS LP) in increasing the shelf life of Domiati cheese. The study compares CCS LP's performance to pomegranate peel extract (PPE) and carboxymethyl chitosan nanoparticles (CCS NPs) alone.
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