Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications.

Breast cancer remains one of the leading causes of cancer-related morbidity and mortality among women worldwide, necessitating the development of novel therapeutic strategies. Phytoconstituents, naturally plant-derived bioactive compounds, have emerged as promising agents for breast cancer therapy due to their multifaceted mechanisms of action. This review examines the role of phytoconstituents in inducing apoptosis, inhibiting breast cancer cell proliferation, and suppressing metastasis.

Phytochemical innovations in oral cancer therapy: targeting oncogenic pathways with natural compounds.

Oral squamous cell carcinoma (OSCC) remains a significant global health concern due to its high mortality rate, late-stage diagnosis, and limited treatment options. Conventional therapies such as surgery, radiotherapy, and chemotherapy often face limitations including drug resistance, recurrence, and systemic toxicity, prompting the need for alternative strategies. This narrative review synthesizes recent preclinical evidence on the use of natural phytochemicals including alkaloids, flavonoids, tannins, saponins, and terpenoids for OSCC treatment.

Microwave-Assisted Synthesis and Characterization of Novel 1,3,4-Oxadiazole Derivatives and Evaluation of In Vitro Antimycobacterial Activity.

Objective The study's goal was to come up with and make a new group of 1,3,4-oxadiazole derivatives (3a-3e) and test how well they could kill (Mtb) H37Rv strain. Additionally, molecular docking and pharmacokinetic properties were analyzed using computational software to identify potential inhibitors, followed by in vitro antimycobacterial assays. Methods A group of 1,3,4-oxadiazoles was prepared by reacting acyl hydrazides with alanine, an N-protected α-amino acid, and a small amount of POCl.

In Silico Evaluation of HIV Protease and RNA Polymerase Inhibitors as Potential COVID-19 Therapeutics.

Background: The COVID-19 coronavirus, also known as the acute respiratory syndrome coronavirus, emerged as a significant global health concern. First identified in Wuhan, China, in December 2019, the virus rapidly spread to over 187 countries due to its high transmissibility. Until an effective treatment or vaccine is developed, preventive measures remain the only mandatory strategy to curb person-to-person transmission.