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A new phenylacetic acid, methoxy-graphislactones C (1), a new anthraquinone (1'E)-6,8-di-O-methyl averanti (2), a new phenanthrene derivative, 12-methyl entonaemin A (3) and five previously reported compounds (4-8) were isolated from the fermented extracts of the mangrove endophytic fungus Aspergillus sp. HMGh1-1. The structures and absolute configurations of the new compounds were determined by spectroscopic techniques (high-resolution mass spectrometry, NMR), ECD calculations, and single-crystal X-ray analysis. Compounds 1-8 were screened for insecticidal activity against Diaphorina citri Kuwayama, and compound 3 exhibited significant insecticidal activity, with a corrected efficacy of 90.97 %.
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http://dx.doi.org/10.1016/j.fitote.2025.106803 | DOI Listing |
Pest Manag Sci
September 2025
National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou, China.
Background: As one of the most destructive and invasive pests for various plants in China, Spodoptera frugiperda (Lepidoptera: Noctuidae) poses an enormous threat to food security and results in serious economic losses for harvesting and consumption of agricultural vegetables. To this end, indoxacarb has shown great promise as an effective insecticide against Spodoptera frugiperda. It is metabolized by insect esterases or amidases into the N-decarbomethoxy metabolite (DCJW), which is a key metabolite responsible for the insecticidal activity of indoxacarb.
View Article and Find Full Text PDFFront Public Health
September 2025
College of Medicine and Health Sciences, Arbaminch University, Arbaminch, Ethiopia.
Background: Long-lasting insecticidal nets (LLINs) are the main vector control tools and remain protective against malaria, even in the presence of high pyrethroid resistance. However, in sub-Saharan Africa, the estimated percentage of the population sleeping under LLINs is low. Hence, this qualitative study was conducted to explore perceptions about LLINs and the reasons for low LLIN use in southern Ethiopia.
View Article and Find Full Text PDFJ Parasitol Res
August 2025
Department of Biology, Wachemo University, Hossana, Ethiopia.
Environmental changes due to global warming and human activities have negatively impacted malaria vector control in Hadiya zone, Ethiopia. Plants contain anthraquinoes. Flavonoids, glycosides, phenol, saponin, steroids, tannin, and terpenes that are target specific, rapidly biodegradable, ecofriendly, and less toxic to human health.
View Article and Find Full Text PDFProtein Pept Lett
September 2025
Center for Advanced Therapeutics, Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Nakornpathom 73170, Thailand.
Background: Bacillus thuringiensis Cry toxins are well known for their insecticidal properties, primarily through the formation of ion-leakage pores via α4-α5 hairpins. His178 in helix 4 of the Cry4Aa mosquito-active toxin has been suggested to play a crucial role in its biotoxicity.
Objective: This study aimed to investigate the functional importance of Cry4Aa-His178 through experimental and computational analyses.
Pestic Biochem Physiol
November 2025
Marine College, Shandong University, Weihai, Shandong 264209, China. Electronic address:
Tralopyril (TP), a representative bromopyrrolonitrile, functions as a broad-spectrum insecticide, raising growing concerns about its potential impact on aquatic organisms and human intestinal health. However, the key targets and toxicity mechanisms underlying TP-induced enteritis remain unclear. In this study, we utilized network toxicology combined with molecular docking to comprehensively explore the potential molecular mechanisms underlying TP-induced enteritis.
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