98%
921
2 minutes
20
Green synthesis of silver nanoparticles (AgNPs) using biological sources has emerged as a sustainable and eco-friendly alternative to conventional chemical and physical methods. This review highlights recent advancements in the green synthesis of AgNPs employing plant extracts, bacteria, fungi, and algae, with particular emphasis on their antioxidant and antibacterial applications. Phytochemicals such as flavonoids, polyphenols, and terpenoids act as natural reducing and stabilizing agents, contributing to the formation of stable nanoparticles with enhanced bioactivity. The unique properties of AgNPs, including their large surface area and unique morphology, enable effective free radical scavenging and potent antibacterial activity, offering promising solutions to oxidative stress-related diseases and multidrug-resistant bacterial infections. This review critically compares green synthesis approaches with traditional methods, outlines their advantages and limitations, and explores the mechanisms underlying the antioxidant and antibacterial actions of AgNPs. The findings highlight the potential of green-synthesized AgNPs in biomedical and environmental applications.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/jemt.70060 | DOI Listing |
J Nat Prod
September 2025
Green Pharmaceutical Technology Key Laboratory of Luzhou City, School of Pharmacy, Southwest Medical University, Luzhou 646000, P. R. China.
Hamigerans, a class of diterpenoid natural products isolated from marine sponge , are characterized by distinctive 6-6-5 or 6-7-5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013.
View Article and Find Full Text PDFSci Adv
September 2025
Key Laboratory of Soybean Disease and Pest Control (Ministry of Agriculture and Rural Affairs), Key Laboratory of Plant Immunity, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Salicylic acid (SA) is a key defense hormone shaped by temperature. High temperatures suppress, while low temperatures enhance, SA biosynthesis and signaling, thereby influencing plant immunity and temperature resilience. This review synthesizes current understanding of how temperature modulates SA pathways and their cross-talk with other hormones to balance growth and defense.
View Article and Find Full Text PDFSci Adv
September 2025
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China.
Insects, unlike vertebrates, use heteromeric complexes of odorant receptors and co-receptors for olfactory signal transduction. However, the secondary messengers involved in this process are largely unknown. Here, we use the olfactory signal transduction of the aggregation pheromone 4-vinylanisole (4VA) as a model to address this question.
View Article and Find Full Text PDFPLoS Pathog
September 2025
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Neuroinflammation within the central nervous system (CNS) is recognized as a critical pathological process in meningitic Escherichia coli (E. coli) infection, leading to severe neurodegenerative disorders and long-term sequelae. Astrocyte reactivity plays a pivotal role in driving the neuroinflammatory cascade in response to pathological stimuli from peripheral sources or other cellular components of the CNS.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
State Key Laboratory of Green Biomanufacturing, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
High-mobility group box protein 1 (HMGB1) is a chromatin-associated nonhistone protein widely distributed in the nucleus of eukaryotic cells. It is transported extracellularly as a proinflammatory mediator or late warning protein to induce immune and inflammatory reactions upon stimuli such as microbial infection. Here, we have found that HMGB1 directly interacts with bacterial DNA analogue CpG-A in the extracellular environment to undergo liquid-liquid phase separation (LLPS) via its positively charged DNA-binding domain.
View Article and Find Full Text PDF