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Article Abstract
Bacterial infection and oxidative stress are major hindrances to wound healing. Designing bioactive wound dressings with inherent antibacterial and antioxidant activities is highly desirable. Herein, a novel multifunctional hydrogel was synthesized via a Schiff-base reaction between the amino groups of sericin and the aldehyde moieties of 2,3,4-trihydroxybenzaldehyde (THBA). The resulting hydrogel exhibited stable mechanical strength, exceptional tissue adhesiveness, and good biocompatibility, along with porous structures, a high swelling ratio, suitable gelation time, and adjustable degradability. experiments confirmed its inherent antibacterial and antioxidant capabilities, while studies using a full-thickness skin wound model in mice revealed accelerated wound healing and enhanced collagen deposition. These findings collectively underscore the potential of the sericin/THBA (SeT) hydrogel as an advanced dressing for effective wound management.
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