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This study aimed to evaluate physical training protocols for alleviating long COVID symptoms, especially dyspnea and fatigue, through a systematic review with meta-analysis. Data were collected from EMBASE, LILACS, PubMed, Scopus, CINAHL, Web of Science, and grey literature (Google Scholar, medRxiv). Studies evaluating dyspnea and/or fatigue before and after physical rehabilitation, using validated questionnaires, were included. Studies lacking pre- and post-assessments or physical training were excluded. Two reviewers independently extracted data on intervention type, duration, frequency, intensity, and assessment methods for dyspnea and fatigue. Bias risk was evaluated using the Cochrane tool. Combined methods, such as respiratory muscle training with strength and aerobic exercise, were common for long COVID symptoms. Aerobic exercise notably improved dyspnea and/or fatigue. Among 25 studies, four had a low risk of bias. Meta-analysis of two studies found no significant reduction in fatigue. Combined training methods, particularly aerobic exercise, alleviate dyspnea and fatigue in long COVID. More high-quality studies are needed to confirm these findings.
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http://dx.doi.org/10.3390/healthcare13151897 | DOI Listing |
Ther Adv Infect Dis
September 2025
Department of Medicine, Division of Infectious Diseases, and Department of Microbiology and Immunology, Stony Brook University, 101 Nicolls Rd, HSC16-027 J, Stony Brook, NY 11794, USA.
Background: Fascioliasis, caused by and , is a neglected tropical disease that has significant medical and veterinary importance. This foodborne zoonotic trematodiases primarily affects poor rural populations in tropical and subtropical areas, where prevalence can be as high as 21%.
Objective: This study aims to characterize the clinical features, laboratory findings, and outcomes of fascioliasis in a real-world cohort.
Geriatr Gerontol Int
September 2025
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Aim: The six-minute walk test (6MWT) allows patients to slow down, stop and rest as needed. However, the prognostic significance of 6MWT interruption remains unclear. Therefore, this study investigated the prognostic implications of 6MWT interruption in patients with heart failure (HF).
View Article and Find Full Text PDFCureus
August 2025
Norton College of Medicine, SUNY Upstate Medical University, Syracuse, USA.
Hydralazine is an antihypertensive that can induce immune-related adverse effects, such as hydralazine-induced lupus and hydralazine-induced antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV). AAV involves necrotizing inflammation of small blood vessels, manifesting as fever, malaise, arthralgia, and myalgia, potentially leading to organ failure. Diagnosis includes clinical evaluation, serological testing for ANCA, and histopathological examination, confirmed by necrotizing granulomatous inflammation in affected tissues.
View Article and Find Full Text PDFEur Heart J Case Rep
September 2025
Advanced Heart Failure and Cardiac Transplant Service, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia.
Background: Diagnosing the cause of undifferentiated left ventricular hypertrophy (LVH) in a patient with progressive heart failure symptoms can present a diagnostic challenge, with potential for both inherited and acquired aetiologies. Hydroxychloroquine-induced cardiomyopathy (HCQ-CM) is a rare complication of long-term hydroxychloroquine use. This case report highlights its clinical presentation, key differential diagnoses, and treatment strategies.
View Article and Find Full Text PDFRespir Med
September 2025
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
Background: Pulmonary marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALToma) is the most common form of primary pulmonary lymphoma. Data on clinic-radiologic presentation, diagnostic methods, and clinical outcome are relatively sparse.
Methods: Retrospective study of 71 patients with biopsy-proven pulmonary MALToma encountered at Mayo Clinic from 1998 to 2022.