Publications by authors named "Taishi Dotare"
Aim: Sarcopenia is a prevalent comorbidity among older patients with heart failure. This study aimed to evaluate the differences between sarcopenia diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2014 and 2019 criteria in older patients with heart failure.
Methods: This study is a post hoc sub-analysis of data from the FRAGILE-HF study, a prospective, multicenter, observational study.
Aims: The prevalence and impact of cardiovascular, kidney, and metabolic (CKM) overlap on physical function and prognosis in older patients with heart failure (HF) remain unclear. This study aimed to assess the impact of overlapping CKM conditions on physical function and prognosis in older patients with HF.
Methods: This post-hoc analysis of the FRAGILE-HF (main cohort) and SONIC-HF (validation cohort), both prospective multicentre studies, included patients aged ≥65 years who were hospitalised for HF.
Background: Heart failure with preserved ejection fraction (HFpEF) remains underdiagnosed in primary care settings, where echocardiography is not available. This study aimed to develop and validate a scoring system that does not include echocardiographic variables for HFpEF screening among patients with shortness of breath.
Methods: A total of 622 consecutive patients referred for exercise stress echocardiography were evaluated (283 HFpEF and 339 controls).
Aims: The benefits of exercise in patients with heart failure are well documented. However, to date, the association between exercise habits and prognosis is yet to be evaluated. In this study, we investigated the association between pre-hospital exercise habits and post-discharge prognosis in older adult patients with heart failure.
View Article and Find Full Text PDFBackground: Renal dysfunction is significantly associated with poor prognosis in patients with heart failure. However, the prognostic significance of proteinuria as a potential marker of an impaired glomerular filtration barrier in acute heart failure (AHF) remains unclear. We aimed to investigate the prognostic value of urinary protein/creatinine ratio (PCR) in patients with AHF.
View Article and Find Full Text PDFBackground And Aims: In patients with heart failure (HF), differences in the association between estimated protein intake (PI) and prognosis in those with and without chronic kidney disease (CKD) remain to be clarified. This study aimed to investigate whether the prognostic effects of the estimated PI differ between patients with HF with and without CKD.
Methods: We included patients who required hospitalisation owing to worsening HF between 2015 and 2019 and assessed the estimated PI based on the adjusted Maroni formula using the body mass index and urinary urea nitrogen level.
Objectives: The Asian Working Group for Sarcopenia in 2019 (AWGS 2019) emphasized muscle mass measurements. In contrast, the Sarcopenia Definitions and Outcomes Consortium (SDOC) prioritizes functional strength and mobility. Therefore, this study aimed to compare the prognostic utility of the SDOC and AWGS 2019 criteria for all-cause mortality in older patients with heart failure.
View Article and Find Full Text PDFMalnutrition is known to worsen the prognosis of chronic heart failure (HF). To gain information that may be helpful in establishing appropriate nutritional interventions for chronic HF, this study was performed to investigate the efficacy of nutritional management with 2 enteral formulas, EH, with a standard nutritional composition, and ER, fortified with omega-3 fatty acids, vitamin D, and carnitine. Experiments were performed in a Dahl rat HF model.
View Article and Find Full Text PDFPrognostic value of Borg scale following 6-min walk test in hospitalized older patients with heart failure.
Eur J Prev Cardiol
December 2024
Aims: The 6-min walk test (6MWT) is a widely accepted tool for evaluating exercise tolerance and physical capacity, and the 6-min walk distance (6MWD) is an established prognostic factor in patients with heart failure (HF). However, the prognostic implications of post-6MWT dyspnoea remain unknown. We aimed to investigate the prognostic value of Borg scores after the 6MWT in patients with HF.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the validity of the AWGS 2019 criteria for diagnosing sarcopenia in heart failure patients and proposed a modified model incorporating the 6-minute walk test (6MWT) for better risk stratification.
- The modified model identified sarcopenia and severe sarcopenia differently than the original, detecting more cases, and showed a stronger link to 2-year mortality rates.
- Findings suggest that using the 6MWT enhances the ability to assess risk in patients with heart failure, indicating a need to revise current criteria for timely treatment decisions.
Aims: In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. In this study, we aimed to assess how novel nutritional-inflammatory markers and lymphocyte-to-C-reactive protein ratio (LCR) and score (LCS) are associated with the nutritional status, physical function, and prognosis of patients with HF.
Methods And Results: This study was a secondary analysis of the FRAGILE-HF study, a prospective observational study conducted across 15 hospitals in Japan.
Background: Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social factors have attracted considerable research attention, information regarding their impact on patients with heart failure is scarce. We aimed to investigate the prognostic impact of objective SI and loneliness in older patients with heart failure.
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- The ALIMENT-HF trial tests the safety and benefits of high-calorie and high-protein oral nutritional supplements (ONS) for older adults with heart failure (HF).
- It involves 80 participants aged 65 and older who are at risk of malnutrition and anorexia, receiving specific ONS for up to 120 days.
- The trial aims to assess changes in body weight and overall nutritional status, which could inform future studies on treating malnutrition in heart failure patients.
Article Synopsis
- The study examined how common bendopnea is in older heart failure patients and its impact on their prognosis.
- Bendopnea was found in 2.5% of patients in the main study group and 4.4% in the validation group, with a higher risk of death over two years for those with this condition.
- The results indicate that bendopnea is a meaningful predictor of all-cause mortality, even when accounting for other risk factors.
Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study.
Circ Cardiovasc Qual Outcomes
May 2024
Article Synopsis
- Frailty in elderly heart failure patients correlates with overall mortality, but specific causes of death remain underexplored, prompting further investigation into multidomain frailty's role.
- The study analyzed 1,181 hospitalized patients, finding that as frailty increased (measured across physical, social, and cognitive domains), so did the risk of death, particularly from noncardiovascular causes.
- Results indicated that patients with higher frailty scores (2 or 3 domains) had a significantly increased risk of noncardiovascular death, while the association was not as strong for heart failure or other cardiovascular deaths.
Article Synopsis
- The study examined how nutrition is assessed and managed for hospitalized heart failure patients by surveying 147 cardiologists across 32 institutions, with a high response rate of 95%.
- Results revealed that while 78.2% of cardiologists performed nutritional assessments, only 38.3% used objective tools and a mere 9.5% evaluated for cardiac cachexia.
- Although 89.8% provided nutritional education before discharge, focus was primarily on sodium and water restrictions, with less attention to protein, micronutrients, and caloric intake, indicating a need for more comprehensive and tailored nutritional guidance.
Background: Current guidelines recommend placing an implantable cardiac defibrillator for patients with cardiac sarcoidosis and a severely impaired left ventricular ejection fraction (LVEF) of ≤35%. In this study, we determined the association between mild or moderate LVEF impairment and fatal ventricular arrhythmic event (FVAE).
Methods And Results: We retrospectively analyzed 401 patients with cardiac sarcoidosis without sustained ventricular arrhythmia at diagnosis.
Aims: MitraScore is a novel, simple, and manually calculatable risk score developed as a prognostic model for patients undergoing transcatheter edge-to-edge repair (TEER) for mitral regurgitation. As its components are considered prognostic in heart failure (HF), we aimed to investigate the usefulness of the MitraScore in HF patients.
Methods And Results: We calculated MitraScore for 1100 elderly patients (>65 years old) hospitalized for HF in the prospective multicentre FRAGILE-HF study and compared its prognostic ability with other simple risk scores.
Background: Frailty is associated with a poor prognosis in older patients with heart failure (HF). However, multidomain frailty assessment tools have not been established in patients with HF, and the association between the frailty phenotype and the deficit-accumulation frailty index in these patients is unclear. We aimed to understand this relationship and evaluate the prognostic value of the deficit-accumulation frailty index in older patients with HF.
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- Researchers aimed to evaluate the Ishii score, which considers age, grip strength, and calf circumference, to predict sarcopenia and its potential impact on 1-year mortality in heart failure patients.
- In a study with 1262 participants, 936 were assessed for sarcopenia, finding that 184 had the condition, with the Ishii score demonstrating good predictive accuracy, especially for men (0.87) compared to women (0.73).
- The results indicated that a higher Ishii score was linked to increased 1-year mortality rates, making it a valuable tool for identifying at-risk older heart failure patients.
A gas exchange analysis with the cardiopulmonary exercise test is effective in discriminating non-cardiogenic components of limited exercise tolerance and is important for use in combination with the diastolic stress test. An 80-year-old woman with progressive exertional dyspnoea, hypertension, and untreated bronchial asthma was diagnosed with heart failure with a preserved ejection fraction by invasive testing. Diuretics were initiated, which resulted in partial symptom improvement.
View Article and Find Full Text PDFPrevalence and prognostic value of atrial fibrillation in patients with cardiac sarcoidosis.
Eur Heart J Open
September 2023
Article Synopsis
- This study investigates how the presence of atrial fibrillation (AF) at the time of cardiac sarcoidosis (CS) diagnosis affects patient outcomes.
- A post-hoc analysis was conducted on data from 445 patients, revealing that those with AF had worse prognoses, indicated by higher levels of brain natriuretic peptide and increased hospitalizations due to heart failure.
- The findings suggest that having AF during CS diagnosis significantly raises the risk of all-cause death and heart failure hospitalization over a median follow-up period of 3.2 years.
Article Synopsis
- This study focused on isolated cardiac sarcoidosis (iCS) to better understand its clinical features and prognosis compared to systemic cardiac sarcoidosis (sCS).
- The analysis included 475 patients, revealing that those with iCS had poorer heart function and a history of atrial fibrillation, but iCS did not show an independent risk factor for poor outcomes after considering other factors.
- Overall, while iCS patients faced more significant heart issues at diagnosis, their long-term prognosis was not worse than that of patients with sCS when adjusting for relevant health factors.
Usefulness of HANBAH Score in Japanese Patients With Acute Heart Failure.
Am J Cardiol
September 2023
Article Synopsis
- The HANBAH score is a new, simple risk assessment tool for patients with acute heart failure, incorporating factors like hemoglobin levels, age, sodium levels, and atrial fibrillation status.
- A study involving 744 hospitalized heart failure patients from 2015 to 2019 validated the HANBAH score, showing a significant association with all-cause mortality and rehospitalization rates.
- Compared to other risk scores, the HANBAH demonstrated superior performance in risk stratification, proving effective even in its simplicity when applied to an external Japanese population.
Prognostic value of estimating appendicular muscle mass in heart failure using creatinine/cystatin C.
Nutr Metab Cardiovasc Dis
September 2023
Article Synopsis
- The study investigates the prognosis of heart failure patients with low appendicular skeletal muscle mass index (ASMI), comparing two methods: an anthropometric model and a biomarker model that includes serum creatinine-to-cystatin C ratio.
- Out of 847 patients, significant differences were noted in how many were diagnosed with low ASMI using these models, highlighting poor agreement between the two methods.
- The results indicate that the biomarker model's prediction of low ASMI is significantly linked to increased risk of all-cause mortality, while the anthropometric model does not show the same predictive power.