Publications by authors named "Yoshikazu Ryuno"
Malnutrition is known to worsen the prognosis of chronic heart failure (HF). To gain information that may be helpful in establishing appropriate nutritional interventions for chronic HF, this study was performed to investigate the efficacy of nutritional management with 2 enteral formulas, EH, with a standard nutritional composition, and ER, fortified with omega-3 fatty acids, vitamin D, and carnitine. Experiments were performed in a Dahl rat HF model.
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- Enteral nutrients play a crucial role in nutrition management, but there's limited guidance on the use of semi-solid enteral nutrients, specifically regarding potential interactions with medications.
- The study focused on how the timing of administering the semi-solid formula RASS affected the pharmacokinetics of sodium valproate (SVA), levetiracetam (LEV), and carbamazepine (CBZ), using plasma concentration measurements.
- Findings showed that while SVA and LEV were unaffected by RASS timing, CBZ's plasma concentrations decreased with delayed administration, though staggered dosing of CBZ and RASS could prevent this interaction.