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Background: The most recent physical activity (PA) monitor data from the US National Health and Nutrition Examination Survey (NHANES) were processed using a novel monitor-independent movement summary (MIMS) algorithm. To date, few studies have utilized these data, likely due to a general unfamiliarity with MIMS-related metrics. The purpose of this study was to establish normative values for peak MIMS metrics as measures of free-living PA intensity and natural ambulatory effort.
Methods: Data from the National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 survey cycles were used, including 8729 individuals aged 20-80+ years. MIMS data were obtained from wrist-worn accelerometers worn for at least 1 valid day (<5% nonwear time per day). Peak-1MIMS (ie, the highest 1-min MIMS value within a day) and Peak-30MIMS (ie, the average of the 30 highest 1-min MIMS values) were obtained, averaged across all valid days, and reported as sample-weighted means (95% confidence intervals), and across 5th to 95th percentiles.
Results: Mean (95% confidence interval) values for Peak-1MIMS and Peak-30MIMS were 59.9 (59.2-61.6) and 42.9 (42.4-43.3) MIMS/minute, respectively. Both peak metrics declined across the adult lifespan. Men displayed greater Peak-1MIMS, while Peak-30MIMS was similar between sexes. Both MIMS metrics trended lower with increasing body mass index.
Conclusion: We provide normative values for peak MIMS metrics which reflect PA intensity/effort. We also developed an R-Shiny App whereby users can input age, sex, body mass index category, and MIMS metrics to determine individual-specific MIMS percentile values. Given the universal nature of the MIMS algorithm, these population representative data may be useful as a reference data set for device-based PA surveillance within the United States and for comparison globally.
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http://dx.doi.org/10.1123/jpah.2025-0182 | DOI Listing |
Genet Med
September 2025
Institute for Clinical and Translational Science, University of California, Irvine, CA, USA.
Purpose: Advancements in sequencing technologies have significantly improved clinical genetic testing, yet the diagnostic yield remains around 30-40%. Emerging technologies are now being deployed to address the remaining diagnostic gap.
Methods: We tested whether short-read genome sequencing could increase the diagnostic yield in individuals enrolled into the UCI-GREGoR research study, who had suspected Mendelian conditions and prior inconclusive testing.
Protein Cell
August 2025
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200433, China.
Cardiovascular disease (CVD) research is hindered by limited comprehensive analyses of plasma proteome across disease subtypes. Here, we systematically investigated the associations between plasma proteins and cardiovascular outcomes in 53,026 UK Biobank participants over a 14-year follow-up. Association analyses identified 3,089 significant associations involving 892 unique protein analytes across 13 CVD outcomes.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Introduction: We compared and measured alignment between the Health Level Seven (HL7) Fast Healthcare Interoperability Resources (FHIR) standard used by electronic health records (EHRs), the Clinical Data Interchange Standards Consortium (CDISC) standards used by industry, and the Uniform Data Set (UDS) used by the Alzheimer's Disease Research Centers (ADRCs).
Methods: The ADRC UDS, consisting of 5959 data elements across eleven packets, was mapped to FHIR and CDISC standards by two independent mappers, with discrepancies adjudicated by experts.
Results: Forty-five percent of the 5959 UDS data elements mapped to the FHIR standard, indicating possible electronic obtainment from EHRs.
Alzheimers Dement
September 2025
Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non-invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular alterations. By synthesizing interdisciplinary evidence, we identify retinal biomarkers as promising tools for early diagnosis and risk stratification.
View Article and Find Full Text PDFObesity (Silver Spring)
September 2025
Division of Hematology, Oncology, and Palliative Care, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Objective: From October 18-20, 2022, the National Institutes of Health held a workshop to examine the state of the science concerning obesity interventions in adults to promote health equity. The workshop had three objectives: (1) Convene experts from key institutions and the community to identify gaps in knowledge and opportunities to address obesity, (2) generate recommendations for obesity prevention and treatment to achieve health equity, and (3) identify challenges and needs to address obesity prevalence and disparities, and develop a diverse workforce.
Methods: A three-day virtual convening.