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Background: Heatstroke is a life-threatening medical emergency characterized by a core body temperature exceeding 40 °C (104°F). Prompt and effective cooling is critical to prevent multiorgan failure and death. However, aggressive cooling techniques, if improperly applied, may lead to iatrogenic complications. We present a pediatric case of severe frostbite injury resulting from direct ice pad application during emergency treatment for heatstroke.
Case Presentation: A 22-month-old infant was found unconscious after being left unattended in a parked car and was diagnosed with severe heatstroke. During prehospital care, direct ice packs were applied per emergency protocol. On admission, erythematous skin lesions were noted on both anterior thighs, which progressed to full-thickness eschars. The plastic surgery team later confirmed these as frostbite injuries. The patient underwent surgical debridement and autologous skin grafting, followed by successful recovery without long-term sequelae.
Conclusion: This case underscores the potential risks associated with rapid cooling interventions, particularly in pediatric patients with more delicate skin. While immediate temperature reduction is vital in treating heatstroke, cooling methods must be carefully selected and monitored. This report highlights the need for pediatric-specific protocols that prioritize both efficacy and safety, and emphasizes the importance of thorough communication between prehospital and in-hospital providers.
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http://dx.doi.org/10.1016/j.jpra.2025.07.009 | DOI Listing |
Langmuir
September 2025
Neutron Scattering Division, Oak Ridge National Laboratory, MS 6473, Oak Ridge, Tennessee 37831 United States.
Mordenite ((Ca,Na,K)AlSiO·7HO) is a natural and synthetic nanoporous zeolite containing several channels of different sizes in its structure. Because of this, its structure provides an important opportunity to study the relationship between confined and ultraconfined water as these channels have sizes between those typical of these water environments. In this study, the properties of water molecules in these environments were analyzed using inelastic and quasielastic neutron spectroscopy of a natural mordenite.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
School of Sports Science and Technology, Guangzhou College of Applied Science and Technology, Guangdong, China.
Objective: This study combines a bibliometric analysis with an umbrella review to delineate the research landscape, hotspots, and emerging trends in the application of artificial intelligence to the clinical diagnosis and treatment of mild cognitive impairment.
Methods: We searched the Web of Science Core Collection for literature published between 2004 and 2024. Bibliometric analysis of the retrieved publications was performed using CiteSpace and VOSviewer to map publication trends, international collaboration networks, key contributors, and keyword co-occurrence.
Macromol Biosci
September 2025
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Conventional gelatin's gel-to-sol transition upon heating restricts its utility in biomedical applications that benefit from a gel state at physiological temperatures such as Pluronic F127 and poly(NIPAAm). Herein, we present "rev-Gelatin", a gelatin engineered with reverse thermo-responsive properties that undergoes a sol-to-gel transition as temperature rises from ambient to body temperature. Inspired by the phase dynamics of common materials like candy and ice cubes, whose surfaces soften or partially melt under warming, facilitating inter-object adhesion- rev-Gelatin leverages this concept to achieve fluidity at room temperature for easy injectability.
View Article and Find Full Text PDFNanoscale
September 2025
School of Mechanical Engineering, Shandong University of Technology, Zibo 255000, China.
Metal matrix composites are widely employed in aerospace and marine engineering due to their excellent mechanical properties and chemical stability. However, their surfaces remain vulnerable to corrosion, icing, and mechanical wear, severely compromising long-term reliability in harsh environments. Inspired by natural superhydrophobic surfaces such as lotus leaves, functional interfaces with high water repellency and interfacial stability can be engineered through the synergistic design of hierarchical micro/nanostructures and low-surface-energy chemical modifications.
View Article and Find Full Text PDFBiogeochemistry
September 2025
Department of Earth Sciences, Uppsala University, Uppsala, 75236 Sweden.
Unlabelled: Ocean surface gravity waves facilitate gas exchanges primarily in two ways: (1) the formation of bubbles during wave breaking increases the surface area available for gas exchange, promoting CO transfer, and (2) wave-current interaction processes alter the sea surface partial pressure of CO and gas solubility, consequently affecting the CO flux. This study tests these influences using a global ocean-ice-biogeochemistry model under preindustrial conditions. The simulation results indicate that both wave-current interaction processes and the sea-state-dependent gas transfer scheme-which explicitly accounts for bubble-mediated gas transfer velocity-influence the air-sea CO flux, with substantial spatial and seasonal variations.
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