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The structural integrity and longevity of aluminum alloy components in lightweight engineering require accurate and efficient damage detection and prognosis methods. Traditional supervised machine learning (ML) techniques often face limitations due to dependency on large datasets, risk of overfitting, and high computational costs. To overcome these challenges, this study proposes an unsupervised learning framework that combines k-means clustering with a multi-phase gamma process to detect and model damage in aluminum plates. Scanning Acoustic Microscopy (SAM) images serve as the data source, from which comprehensive features are extracted in time, frequency, and time-frequency domains using Short-Time Fourier Transform (STFT). The K-means algorithm enables precise localization and sizing of surface defects without prior labels, while the gamma process captures the stochastic progression of damage over time. The method demonstrates high accuracy in estimating defect geometry and prognostic trajectories while maintaining low computational complexity. This unified, interpretable approach is generalizable to a range of materials and holds strong potential for real-time structural health monitoring (SHM) in safety-critical domains.
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http://dx.doi.org/10.1038/s41598-025-13189-8 | DOI Listing |
Diabetes Metab J
September 2025
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Diabetic foot ulcer (DFU) represents a challenging complication of diabetes mellitus, characterized by slow healing processes. Protein kinase C delta (PKCδ) has been identified as a significant factor in the pathogenesis of various diabetic complications, including DFU. However, the precise underlying mechanisms remain to be fully elucidated.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2025
Department of Mechanical Engineering, Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Albumin and γ-globulin concentrations in an electrolyte solution have been quantified by a multivariate-regressive Gaussian admittance relaxation times distribution (mgARTD). The mgARTD is built based on the training data consisting of the impedance spectroscopy system measurement result of protein mixture solutions with a known concentration of albumin, γ-globulin, and sodium electrolyte to perform concentration quantification on a prospective protein mixture solution with an unknown concentration. The mgARTD consists of three steps: (1) Prediction step of the peak matrix by Gaussian ARTD (gARTD) with the Gaussian process and peak detection algorithm, (2) Training step of the approximated coefficient matrix ̃ based on the multivariate-regressive formula = + (: multivariate-regression coefficient matrix, : error matrix, and : known concentration matrix of the training data set), and (3) Quantification step of the approximated concentration ̃ based on the Gauss-Newton algorithm from the predicted of the quantification data and the approximated ̃.
View Article and Find Full Text PDFEur J Neurosci
September 2025
Experimental Psychology I, Institute of Psychology, Osnabrück University, Osnabrück, Germany.
Initial findings linking Virtual Reality (VR)-based encoding to increased recollection at retrieval remain inconclusive due to heterogeneous study designs and dependence on behavioral data. To clarify under which circumstances VR-based encoding affects or enhances episodic memory retrieval, the fundamental question remains whether the encoding modality, i.e.
View Article and Find Full Text PDFImmunol Invest
September 2025
Respiratory and Critical Care Medicine, The 940th Hospital of Joint Logistics Support Force of chinese PLA, Lanzhou, China.
Background: Pulmonary neuroendocrine cells (PNECs) are specialized airway epithelial cells with dual sensory and secretory functions. They release bioactive mediators --including neuropeptides such as calcitonin gene-related peptide (CGRP) and gastrin-releasing peptide (GRP), and neurotransmitters such as 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA) --that regulate airway smooth-muscle tone, mucus production, and immune responses. In chronic obstructive pulmonary disease (COPD), these PNEC-derived mediators contribute to airway inflammation, remodeling, and smooth-muscle dysfunction.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing 211800, PR China. Electronic address:
The insect ionotropic γ-aminobutyric acid (GABA) receptor is an important insecticide target, and alternative splicing (AS) among exons 3a, 3b, 6a, and 6b of its RDL subunit is ubiquitous in insects; however, the AS factors and mechanisms remain unclear. While the neuro-oncological ventral antigen (Nova) is known to regulate AS of the γ2 subunit of mammalian GABA receptors, its role in insects remains unexplored. Two CsNova isoforms, CsNova-X1 and CsNova-X3, were identified by BLAST in the third-generation transcriptome of Chilo suppressalis.
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