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In this paper, we propose a one-dimensional polarization beam splitting grating under normal incidence with excellent polarization characteristics and a high diffraction efficiency. The main structure is a double-groove slanted grating. We employed a rigorous coupled-wave analysis and simulated annealing algorithm for numerical calculations of the grating. The optimized grating structure can concentrate the energy of TE-polarized light at the -1 order and the energy of TM-polarized light at the 0th order under normal incidence. The analysis results indicate that at the incident wavelength of 1550 nm, the diffraction efficiency is 93.549% for TE polarization and 93.522% for TM polarization, with an extinction ratio greater than 14 dB. To the best of our knowledge, this is the first report of a one-dimensional polarization beam splitter grating with a transmissive double-groove slanted grating under normal incidence. This grating shows great potential for applications in polarization measurement, imaging, and grating encoders.
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http://dx.doi.org/10.1364/AO.546716 | DOI Listing |
Int J Surg
September 2025
Department of Gynecology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Background: Ovarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than five years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to 2021 and also project its prevalence to 2050, providing insights into these evolving patterns and helping health policymakers use healthcare resources more effectively.
Methods: This study comprehensively analyzes the original data related to ovarian cancer from the GBD 2021 database, employing a variety of methods including descriptive analysis, correlation analysis, age-period-cohort (APC) analysis, decomposition analysis, predictive analysis, frontier analysis, and health inequality analysis.
Med Oncol
September 2025
Division of Hematology and Blood Bank, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Acute Myeloid Leukemia (AML) patient-derived Mesenchymal Stem Cells (MSCs) behave differently than normal ones, creating a more protective environment for leukemia cells, making relapse harder to prevent. This study aimed to identify prognostic biomarkers and elucidate relevant biological pathways in AML by leveraging microarray data and advanced bioinformatics techniques. We retrieved the GSE122917 dataset from the NCBI Gene Expression Omnibus and performed differential expression analysis (DEA) within R Studio to identify differentially expressed genes (DEGs) among healthy donors, newly diagnosed AML patients, and relapsed AML patients.
View Article and Find Full Text PDFFam Cancer
September 2025
School of Social Policy and Practice, University of Pennsylvania, Philadelphia, USA.
Li-Fraumeni syndrome (LFS) is an early-onset cancer syndrome caused by pathogenic germline TP53 variants. Adolescents and young adults (AYAs) with LFS may have challenges navigating new romantic partnerships given the significant effects of LFS on multiple life domains that also affect partners (e.g.
View Article and Find Full Text PDFJ Eval Clin Pract
September 2025
School of Public Health, Wuhan University, Wuhan, China.
Background: Social support can have health benefits but may also pose risks for the elderly, particularly those facing conflicts and network disruptions. Understanding the short and long-term mental health effects, especially in elderly individuals with chronic illnesses, is crucial due to global depression concerns. Yet, research is limited, with gaps in exploring different social disruption scenarios and lacking comprehensive multi-period data analysis.
View Article and Find Full Text PDFCochrane Database Syst Rev
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.
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