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Processing the optimal length of electrode arrays for cochlear implants (CIs) is vital for achieving maximum effectiveness, and the results tend to differ between the preoperative radiological estimations and the depth reached at the time of surgery. This study evaluates the feasibility of using a flexible insertion test electrode with colored depth markers to determine the practically achievable electrode insertion depth before CI electrode array placement. The study was conducted at a tertiary center and included patients with inner ear anomalies, reimplantation cases, and profound deafness with no residual hearing. A custom insertion test electrode, 31.5 mm long, was inserted into the scala tympani (ST) to assess cochlear lumen accessibility. Standard CI surgical procedures were followed, including impedance field telemetry testing and evoked compound action potential measurements. A total of 10 patients (11 ears), aged 1 to 29, met the inclusion criteria. The proposed test electrode enabled real-time determination of insertion depth, allowing the surgeon to tailor electrode lengths to the most suitable depth for implantation. This advancement mitigated incomplete insertion and improved preoperative planning. This research describes a new approach for setting the limits of electrode selection that minimizes the complications of electrode placement during cochlear implantation. The proposed insertion test electrode could help achieve better accuracy in surgery and, consequently, better outcomes for patients with cochlear implants.
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http://dx.doi.org/10.3791/68373 | DOI Listing |
Anal Chem
September 2025
Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, China.
Despite the promise of electrochemical biosensors in amplified nucleic acid diagnostics, existing high-sensitivity platforms often rely on a multilayer surface assembly and cascade amplification confined to the electrode interface. These stepwise strategies suffer from inefficient enzyme activity, poor mass transport, and inconsistent probe orientation, which compromise the amplification efficiency, reproducibility, and practical applicability. To address these limitations, we report a programmable dual-phase electrochemical biosensing system that decouples amplification from signal transduction.
View Article and Find Full Text PDFJ Org Chem
September 2025
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
A novel electrochemical/Fe dual-catalyzed perfluoroalkylation-thiolization of alkenes under mild conditions has been developed. This protocol utilizes commercially available reagents, cheap electrodes, and simple equipment. Diverse polyfunctionalized perfluoroalkyl-substituted derivatives were successfully obtained in a direct and efficient way with a broad substrate scope and excellent functional group tolerance.
View Article and Find Full Text PDFNanomicro Lett
September 2025
Department of Mechanical, Aerospace & Biomedical Engineering, University of Tennessee, Knoxville, Knoxville, TN, 37996, USA.
3D printing, as a versatile additive manufacturing technique, offers high design flexibility, rapid prototyping, minimal material waste, and the capability to fabricate complex, customized geometries. These attributes make it particularly well-suited for low-temperature hydrogen electrochemical conversion devices-specifically, proton exchange membrane fuel cells, proton exchange membrane electrolyzer cells, anion exchange membrane electrolyzer cells, and alkaline electrolyzers-which demand finely structured components such as catalyst layers, gas diffusion layers, electrodes, porous transport layers, and bipolar plates. This review provides a focused and critical summary of the current progress in applying 3D printing technologies to these key components.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea.
Wearable bioelectronics have advanced dramatically over the past decade, yet remain constrained by their superficial placement on the skin, which renders them vulnerable to environmental fluctuations and mechanical instability. Existing microneedle (MN) electrodes offer minimally invasive access to dermal tissue, but their rigid, bulky design-often 100 times larger and 10,000 times stiffer than dermal fibroblasts-induces pain, tissue damage, and chronic inflammation, limiting their long-term applicability. Here, a cell-stress-free percutaneous bioelectrode is presented, comprising an ultrathin (<2 µm), soft MN (sMN) that dynamically softens via an effervescent structural transformation after insertion.
View Article and Find Full Text PDFLangmuir
September 2025
College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China.
Sodium-ion batteries are promising candidates for large-scale energy storage due to their low cost and resource abundance. However, their cathode materials suffer from poor conductivity and limited cycling stability. Here, we report a Prussian blue (PB)-based cathode hybridized with carboxyl-functionalized carbon nanotubes (CNTs) via a glutamic acid-assisted in situ coordination route.
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