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http://dx.doi.org/10.1002/joa3.70165 | DOI Listing |
Int J Nanomedicine
September 2025
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Introduction: Oral squamous cell carcinoma (OSCC) has a poor prognosis due to its immunosuppressive tumor microenvironment (TME), in which tumor-associated macrophages (TAMs) play a pivotal role in promoting disease progression and therapeutic resistance. This study examines whether Prussian blue nanoparticles (PB NPs) could reprogram TAMs and block tumor-stroma communication in OSCC.
Methods: PB NPs were synthesized using polyvinylpyrrolidone-assisted coprecipitation and characterized by transmission electron microscopy, dynamic light scattering, and UV-Vis spectroscopy.
Oncol Res
September 2025
Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, 415000, China.
Background: The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer.
Methods: Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models.
Oncol Res
September 2025
Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, 610041, China.
Objectives: Ovarian cancer, a leading cause of gynecological malignancy-related mortality, is characterized by limited therapeutic options and a poor prognosis. Although pyrimethamine has emerged as a promising candidate demonstrating efficacy in treating various tumors, the precise mechanisms of its antitumor effects remain obscure. This study was specifically designed to investigate the mode of action underlying the antitumor effects of pyrimethamine in preclinical settings.
View Article and Find Full Text PDFJSLS
September 2025
Department of Urology, University of Health Sciences Medical Faculty of Kayseri, Kayseri City Hospital, Kayseri, Turkiye. (Drs. Golbasi, Karadag, Elmaagac).
Background: Inguinal hernia repair (IHR) is a common procedure, and patients with a history of IHR may later require radical prostatectomy. Prior IHR can complicate prostatectomy by altering anatomy, but its impact on extraperitoneal laparoscopic radical prostatectomy (ELRP) remains unclear. This study evaluates the feasibility and outcomes of ELRP in patients with prior IHR.
View Article and Find Full Text PDFJSLS
September 2025
Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine, Morgantown, West Virginia, USA. (Dr. Cox).
Background And Objectives: Electronic data capture may enhance efficiency and patient engagement in preoperative psychosocial evaluations for metabolic and bariatric surgery yet concerns persist about its feasibility in rural populations with historically lower mobile health adoption. This study evaluated the feasibility and acceptability of electronic patient-reported outcomes among metabolic and bariatric surgery patients in a rural setting.
Methods: In this quality improvement project, 202 patients undergoing presurgical psychosocial evaluation at an academic medical center in rural West Virginia completed a battery of psychological assessments on a clinic-provided tablet.