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Article Abstract
Tumor-associated macrophages (TAMs) are pivotal immunoregulatory cells in the tumor microenvironment (TME). They play a central role in tumor progression through dynamic regulation of metabolic reprogramming, especially lipid metabolism. TAMs switch between pro-tumor (M2) and anti-tumor (M1) phenotypes through a high degree of plasticity. This process is regulated by fatty acid oxidation (FAO), cholesterol homeostasis and phospholipid metabolism. Targeting TAMs lipid metabolism provides a new strategy for remodeling the anti-tumor tumor microenvironment, and its synergistic effect with tumor immunotherapy such as immune checkpoint inhibitors is expected to be a new direction for precision tumor therapy.
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| http://dx.doi.org/10.1016/j.critrevonc.2025.104881 | DOI Listing |
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