Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aim & Objective: We have reported that T-cadherin (T-cad), a glycosylphosphatidylinositol-anchored protein that specifically binds to adiponectin, exists in the human serum as a soluble form (sT-cad). sT-cad promotes pancreatic β-cell proliferations, indicating a potential organ-protective role. This study aimed to the cardioprotective effect of sT-cad.
Methods & Results: The sT-cad-expressing plasmid was administered to 7-week-old wild-type mice. One week after administration, transverse aortic constriction (TAC) surgery was performed to induce pressure-overload heart failure. Then, the mice were sacrificed at 2 weeks after the surgery. In the mice that received sT-cad, the TAC-induced increase in heart weight and decline in cardiac function were significantly attenuated. Based on the cardiac histological analysis, sT-cad suppressed both cardiomyocyte hypertrophy and cardiac fibrosis. Cardiac RNA sequencing analysis showed that sT-cad inhibited the TAC-induced upregulation of fibrosis-related genes. In addition, in NIH-3T3 fibroblasts, sT-cad supplementation suppressed the TGF-β-induced mRNA expression of Acta2, a myofibroblast marker.
Conclusion: sT-cad ameliorated the pressure overload-induced heart failure in mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2025.152459 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches.
ESC Heart Fail
September 2025
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Heart failure (HF) is a multifactorial and pathophysiological complex syndrome, involving not only neurohormonal activation but also oxidative stress, chronic low-grade inflammation, and metabolic derangements. Central to the cellular defence against oxidative damage is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that orchestrates antioxidant and cytoprotective responses. Preclinical in vitro and in vivo studies reveal that Nrf2 signalling is consistently impaired in HF, contributing to the progression of myocardial dysfunction.
View Article and Find Full Text PDFApplication of stereotactic radiotherapy in the treatment of cardiovascular diseases through sympathectomy.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Sympathectomy, as an emerging treatment method for cardiovascular diseases, has received extensive attention in recent years. Stereotactic radiotherapy (SRT), a precise and noninvasive therapeutic technique, has gradually been introduced into interventions targeting the sympathetic nervous system and has shown promising prospects in the management of cardiovascular conditions. Using three-dimensional imaging, SRT can accurately localize sympathetic ganglia and deliver high-energy radiation to disrupt nerve fibers, thereby achieving effects similar to conventional sympathectomy while reducing surgery-related complications and shortening recovery time.
View Article and Find Full Text PDFLetter regarding the article 'Association between antecedent myocardial infarction and heart failure with preserved versus reduced ejection fraction'.
Eur J Heart Fail
September 2025
Evidence-based Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
Reply to the letter regarding the article 'Association between antecedent myocardial infarction and heart failure with preserved versus reduced ejection fraction'.
Eur J Heart Fail
September 2025
Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS-HF trial.
Eur J Heart Fail
September 2025
Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Aims: The estimated glucose disposal rate (eGDR) is a simple, non-invasive measure of insulin resistance. In this exploratory analysis of FINEARTS-HF, we evaluated whether lower eGDR, reflecting greater insulin resistance, is associated with adverse outcomes in heart failure (HF).
Methods And Results: The eGDR was calculated at baseline using waist circumference, glycated haemoglobin, and hypertension status.