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Article Abstract
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent life-threatening blood clots and pregnancy complications in individuals with antiphospholipid antibodies. Among these antibodies, those targeting the plasma glycoprotein β-glycoprotein I (βGPI) hold particular clinical significance. Despite extensive research, controversies persist regarding the structure of βGPI, which has substantial implications for understanding autoantibody reactivity and APS development. This article critically examines recent advancements in the structural biology of βGPI and its relevance to the recognition of antiphospholipid antibodies. Additionally, it introduces a new structure-based theory to explain how autoantibodies interact with βGPI and the functional consequence of this interaction. Finally, it identifies potential areas for future research that could enhance approaches to diagnosing and treating APS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320411 | PMC |
| http://dx.doi.org/10.1016/j.bvth.2024.100041 | DOI Listing |
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