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pH and temperature in the gastrointestinal (GI) tract are correlated with many diseases, but patients suffer from the pain of traditional testing methods. Functionalized capsule robots for GI tract sensing offer a potential approach for early GI disease diagnosis. However, most capsule robots struggle with control and sensing integration. In addition, the friction encountered by capsule robots during navigation poses a challenge for their application. Here, a capsule robot with a low coefficient of friction is proposed to continuously detect pH and temperature. The hydrogel skin reduces the surface friction coefficient by more than 4 times and achieves an average propulsion speed of 12.79 mm s in a living porcine small intestine. The capsule system enables continuous detection over a pH range of 2 to 8 and a temperature of 36 to 40 °C. We demonstrate capsule robots' capability of multimodal locomotion through complex stomach and small intestine environment. It solves the problem that capsule robots used for sensing functions cannot be precisely controlled and achieves drive-control-sensing integration.
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http://dx.doi.org/10.34133/research.0807 | DOI Listing |
ILIVER
September 2025
Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China.
Anatomic resection remains a fundamental principle in the surgical management of hepatobiliary diseases, whether performed through traditional open surgery or advanced minimally invasive approaches such as laparoscopic or robotic-assisted techniques. However, a universally accepted and clearly defined anatomical framework for intraoperative anatomical delineation remains lacking. The growing clinical adoption of Laennec membrane-guided anatomical strategies has been associated with notable improvements in surgical efficacy and anatomical precision.
View Article and Find Full Text PDFAsian Spine J
August 2025
National Spine Injuries Unit, Mater Misericordiae University Hospital, Dublin, Ireland.
Facet joint violation (FJV) is a known complication of pedicle screw fixation that may contribute to adjacent segment disease (ASD) by altering spinal biomechanics and increasing loading of the cranial facet joints. However, the prevalence, biomechanical effects, and longterm consequences of FJV remain unclear. A scoping review was conducted using the PubMed, Embase, and Scopus databases.
View Article and Find Full Text PDFNPJ Parkinsons Dis
August 2025
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and in cholinergic white matter. However, it remains unknown if the higher WMSA in cholinergic white matter reflects selective cholinergic vulnerability or results from higher global WMSA.
View Article and Find Full Text PDFJ Neurosurg Pediatr
August 2025
1Department of Neurosurgery, UMass Chan Medical School.
Objective: Stereotactic gene therapy in children is challenging due to the fragility of the infant skull and long hours of infusion. The thalamus, an integrative hub for the entire cortex, has been shown to facilitate widespread gene/protein delivery via axonal transport. The aim of this study was to evaluate the safety and accuracy of bilateral thalamic convection-enhanced delivery (CED) of adeno-associated virus (AAV) vectors for GM2 gangliosidoses in children and to assess outcomes based on post-infusion imaging.
View Article and Find Full Text PDFDiagnostics (Basel)
July 2025
Department of Morpho-Functional Sciences I, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
: Degenerative processes of the hip joint increasingly affect not only the articular cartilage but also periarticular structures such as the joint capsule and acetabular labrum. This study aimed to investigate the structural and molecular changes occurring in these tissues during advanced hip osteoarthritis. : A combined analysis using immunohistochemistry (IHC), scanning electron microscopy (SEM), and micro-computed tomography (microCT) was conducted on tissue samples from patients undergoing total hip arthroplasty and from controls with morphologically normal joints.
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