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| http://dx.doi.org/10.1016/j.parkreldis.2025.107964 | DOI Listing |
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Olfactory training improves cognition and modifies brain networks in type 2 diabetes patients with mild cognitive impairment: A 16-week randomised controlled trial.
Diabetes Obes Metab
September 2025
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Aims: Type 2 diabetes (T2D) related cognitive impairment links to comorbid and modifiable olfactory dysfunction; however, the efficacy of olfactory training (OT) to mitigate cognitive decline specifically in these patients with mild cognitive impairment (MCI) remains unestablished. This study aimed to determine whether OT alleviates cognitive decline in this population.
Materials And Methods: In this 16-week, open-label trial, 60 T2D participants with MCI were randomly assigned (1:1) to OT or routine care (control).
Functional connectivity signatures of olfactory networks linked to cognitive risk: A functional MRI study in subjective cognitive decline at risk for Alzheimer's disease.
J Alzheimers Dis
September 2025
Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
BackgroundIndividuals with subjective cognitive decline (SCD) are at high risk of preclinical Alzheimer's disease (AD). While olfactory dysfunction is evident in AD and mild cognitive impairment (MCI), its presence and neural mechanism in SCD remain unclear.ObjectiveThis study examined functional connectivity (FC) alterations across olfactory networks and their mediating role between olfactory and cognitive functions in SCD and MCI.
View Article and Find Full Text PDFSemantical Visual Information Facilitates Odor Imagery: A Combined Neurophysiological and Psychometrical Approach.
Brain Behav
September 2025
Université De Lorraine, Inserm, IADI, Nancy, France.
Introduction: Odor imagery (OI), or the ability to mentally simulate the presence of a smell, is a difficult cognitive function and is therefore misunderstood in terms of its neural underpinnings. In particular, the diverging results obtained in neuroimaging studies could be explained in part by the characteristics of the visual cues used to trigger this task. In this study, we investigated this question by comparing the effects of plain color patches, pictures, and words during OI using neurophysiological and psychometrical measurements.
View Article and Find Full Text PDFST-deconv: an accurate deconvolution approach for spatial transcriptome data utilizing self-encoding and contrastive learning.
NAR Genom Bioinform
September 2025
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518005 Guangdong, China.
Single-cell RNA sequencing (scRNA-seq) has significantly deepened our understanding of cellular heterogeneity and cell type interactions, providing insights into how cell populations adapt to environmental variability. However, its lack of spatial context limits intercellular analysis. Similarly, existing spatial transcriptomics (ST) data often lack single-cell resolution, restricting cellular mapping.
View Article and Find Full Text PDFConnectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.
bioRxiv
August 2025
Department of Biology, West Virginia University, Morgantown, United States of America.
Inhibitory local interneurons (LNs) play an essential role in sensory processing by refining stimulus representations via a diverse collection of mechanisms. The morphological and physiological traits of individual LN types, as well as their connectivity within sensory networks, enable each LN type to support different computations such as lateral inhibition or gain control and are therefore ideal targets for modulatory neurons to have widespread impacts on network activity. In this study, we combined detailed connectivity analyses, serotonin receptor expression, neurophysiology, and computational modeling to demonstrate the functional impact of serotonin on a constrained LN network in the olfactory system of .
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