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Article Abstract
Ten cyclopeptides were isolated from the 70 % ethanol extract of Lycii Cortex and identified by physical and chemical properties and various spectroscopic methods. They were named as lyciumin E (1), lyciumin G (2), lyciumin F (3), lyciumin B methyl ester (4), lyciumin A methyl ester (5), lyciumin C methyl ester (6), lyciumin A (7), lyciumin B (8), lyciumin C (9) and lyciumin D (10). Among them, compounds 1-3 were new cyclopeptides, compound 4 was a new natural product, and compounds 5 and 6 were first isolated from this plant. The anti-inflammatory activity and mechanism of compounds 7-9 were studied in vitro. The results showed that compounds 7-9 could play an anti-inflammatory role by inhibiting the expression of IL-6 and TNF-α mRNA in RAW264.7 inflammatory cells induced by LPS and reducing the secretion of NO, IL-6 and TNF-α in the cell supernatant.
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Three new cyclopeptides from the Lycii cortex.
Fitoterapia
September 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, People's Republic of China; The Key Research Laboratory of "Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine", The State Administration of Traditional Chinese Me
Ten cyclopeptides were isolated from the 70 % ethanol extract of Lycii Cortex and identified by physical and chemical properties and various spectroscopic methods. They were named as lyciumin E (1), lyciumin G (2), lyciumin F (3), lyciumin B methyl ester (4), lyciumin A methyl ester (5), lyciumin C methyl ester (6), lyciumin A (7), lyciumin B (8), lyciumin C (9) and lyciumin D (10). Among them, compounds 1-3 were new cyclopeptides, compound 4 was a new natural product, and compounds 5 and 6 were first isolated from this plant.
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Proc Natl Acad Sci U S A
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Whitehead Institute for Biomedical Research, Cambridge, MA 02142;
The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class of plant ribosomal peptides, the branched cyclic lyciumins. Initially isolated from the Chinese wolfberry , lyciumins are protease-inhibiting peptides featuring an N-terminal pyroglutamate and a macrocyclic bond between a tryptophan-indole nitrogen and a glycine α-carbon.
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State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Two cyclopeptides, celogentin L (1) and its epimer lyciumin A (2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1D-, 2D-NMR, and HR-ESI/MS.
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