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Article Abstract
A novel therapeutic strategy for form deprivation myopia (FDM) involving Timp2-modified scleral stem cells (SSC) embedded in gelatin-hydroxyphenylpropionic acid (Gtn-HPA) hydrogel was investigated. Transcriptome and single-cell RNA sequencing analyses identified Timp2 as a crucial factor in FDM progression due to its reduced expression in FDM sclera. The developed SSC-Gtn-HPA hydrogel composite demonstrated excellent biocompatibility, rapid gelation, and degradation properties. studies showed that SSC-GH promoted human scleral fibroblast (HSF) proliferation, inhibited apoptosis, and prevented differentiation. experiments in mice showed that SSC-GH effectively regulated ocular parameters, facilitated scleral recovery, and improved FDM conditions. These results highlight the potential of SSC-GH as a promising therapeutic approach for myopia treatment by enhancing scleral recovery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268941 | PMC |
| http://dx.doi.org/10.1016/j.mtbio.2025.101942 | DOI Listing |
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