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Article Abstract
Background: Vitamin deficiencies have been reported to cause brain atrophy. Hippocampal atrophy has been well reported in patients with dementia including Alzheimer's disease.
Objectives: To investigate the association between hippocampal atrophy and vitamin deficiency DESIGN: Cross sectional study SETTING: Three sites in one country PARTICIPANTS: Overall, 567 patients who visited an outpatient dementia clinic and underwent MRI-VSRAD (Voxel-Based Specific RegionalAnalysis System for Alzheimer's Disease) were included in this study.
Intervention: Patients with a hippocampal atrophy Z-score of < 2 were classified as normal (n = 323), and those with a Z-score of ≥ 2 were diagnosed with hippocampal atrophy (n = 244).
Measurements: Vitamin B, folic acid, vitamin B, homocysteine, HbA1c, and creatinine levels were measured and their association with hippocampal atrophy was assessed. Age, MMSE (Mini Mental State Examination), and hippocampal atrophy were also evaluated.
Results: In the hippocampal atrophy group, the frequency of vitamin B deficiency was higher (p < 0.022), MMSE score was lower (p < 0.0001), and age was higher (p < 0.0001) than that in the normal group (Mann-Whitney U test). Patients with vitamin B deficiency (odds ratio, 3.46) and low MMSE score (odds ratio, 2.24) had an increased risk of hippocampal atrophy.
Conclusion: Vitamin B deficiency was associated with hippocampal atrophy detected by VSRAD analysis. Therefore, early vitamin B supplementation should be considered in patients with deficiencies to reduce dementia risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413733 | PMC |
| http://dx.doi.org/10.1016/j.tjpad.2025.100265 | DOI Listing |
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