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http://dx.doi.org/10.1055/a-2638-5469 | DOI Listing |
Med Phys
August 2025
Department of Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, People's Republic of China.
Background: Accurate prediction of lung tumor motion and deformation (LTMD) is essential for precise radiotherapy. However, existing models often rely on static, population-based material parameters, overlooking patient-specific and time-varying lung biomechanics. Personalized dynamic models that capture temporal changes in lung elasticity are needed to improve LTMD prediction and guide treatment planning more effectively.
View Article and Find Full Text PDFJ Dent (Shiraz)
September 2025
Dept. of Orthodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Relapse is acknowledged as a substantial failure after orthodontic correction. As a biomarker of bone formation, alkaline phosphatase (ALP) levels will decline in compressive sites during relapse subsequent to orthodontic tooth displacement. Manipulating alveolar bone remodeling to elevate ALP levels using novel biomaterial is presently regarded as one of the innovative approaches to avert relapse effectively.
View Article and Find Full Text PDFJ Pharm Anal
August 2025
School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, China.
Computational approaches, encompassing both physics-based and machine learning (ML) methodologies, have gained substantial traction in drug repurposing efforts targeting specific therapeutic entities. The human dopamine (DA) transporter (hDAT) is the primary therapeutic target of numerous psychiatric medications. However, traditional hDAT-targeting drugs, which interact with the primary binding site, encounter significant limitations, including addictive potential and stimulant effects.
View Article and Find Full Text PDFJ Med Chem
September 2025
Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.
BRD4, a bromodomain-containing protein, has emerged as an attractive therapeutic target for various diseases. Selective inhibition of the bromodomain is gaining traction as a promising strategy for targeted drug discovery. Based on bioisosterism-guided optimization of RVX-OH (), a pan-BET inhibitor, we designed and synthesized a series of novel quinazolin-4(3)-one derivatives as potent BRD4 inhibitors.
View Article and Find Full Text PDFSurg Innov
August 2025
Department of General and Gastroenterological Surgery, Osaka Me Dical and Pharmaceutical University Hospital, Takatsuki, Japan.
BackgroundSingle port cholecystectomy (SPC) provides several postoperative advantages including excellent cosmetic outcomes; however, it presents technical challenges due to impaired triangulation and restricted instrument mobility. To address these challenges, we developed the FJB method, a novel liver retraction technique combining Free Jaw (FJ) clips with barbed sutures.MethodsIn the FJB method, an FJ clip is applied near the base of the gallbladder, and a barbed suture is anchored to the diaphragm, enabling cephalad traction via a pulley-like mechanism.
View Article and Find Full Text PDF