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Biological embedding of stress is a process commonly observed among individuals with histories of early life adversity. Adverse experiences can get "under the skin" and influence the neural and biological characteristics of an individual, impacting a range of health domains including inflammation. This study aimed to identify characteristics that protect individuals against immune health challenges following childhood abuse (e.g., physical, emotional, sexual). Childhood self-regulation and peer likeability were tested as moderators in the effects of abuse on emerging adulthood inflammation. Participants (N = 421) were drawn from a follow-up study of emerging adults with and without maltreatment histories who participated in a research camp program as children. Maltreatment was determined based on CPS record data, self-regulation was informed by camp counselor report, peer likeability was indicated through camp participants' ratings, and adulthood inflammation was identified via salivary C-reactive protein (CRP). Results indicated that childhood abuse did not have a significant main effect on emerging adulthood inflammation. However, among youth who were more behaviorally disinhibited, the experience of abuse was predictive of lower inflammation. Peer likeability did not significantly moderate the association between abuse and inflammation. Results underscore how multifinality in health outcomes following abuse, including resilience, may be shaped by individual characteristics.
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http://dx.doi.org/10.1177/10775595251358395 | DOI Listing |
J Nutr Biochem
September 2025
Department of Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:
Background: Individuals born after intrauterine growth restriction (IUGR) have a higher risk of developing metabolic syndrome (MetS) in adulthood. In a rat model, male IUGR offspring exhibit MetS features-including elevated systolic blood pressure, glucose intolerance, non-alcoholic fatty liver disease, and increased visceral adipose tissue (VAT)-by 6 months of age. Female offspring, however, do not.
View Article and Find Full Text PDFFront Immunol
September 2025
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
In order to preserve homeostasis, macrophages-phagocytic innate immune cells-interact with different tissue types, modulating immunological responses and secreting a variety of cytokines. They are extensively dispersed throughout the body's tissues and organs. Based on their developmental origins, tissue-resident macrophages (TRMs) in humans can be classified into those of embryonic origin and those derived from bone marrow-derived monocytes (BMDMs); embryonically derived macrophages emerge during early development, possess self-renewal capacity, and persist into adulthood in specific tissues such as microglia in the brain and Kupffer cells in the liver, whereas BMDMs originate from hematopoietic stem cells in the bone marrow via monocytic differentiation, infiltrate tissues during inflammation or injury, and differentiate into macrophages that transiently reside in tissues but lack self-renewal capability, thus requiring continuous replenishment.
View Article and Find Full Text PDFAm J Hypertens
August 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Background: The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adulthood body size on GDM risk, and explore inflammation's role.
Methods: Using female-specific UK Biobank genome-wide association study data, genetic instruments for childhood/adult body size ("thinner," "about average," "plumper") and C-reactive protein (CRP) were identified.
Environ Res
September 2025
Department of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Denmark; Department of Public Health, Section of Environmental Health, University of Copenhagen, Denmark.
Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may influence lung and immune system development, but previous epidemiological studies are inconclusive and have not extended into young adulthood.
Objective: To examine associations between prenatal exposure to a mixture of PFAS and respiratory and immune-related outcomes in a cohort of males.
Methods: We studied 866 males with maternal pregnancy plasma measured for 15 PFAS, triclosan, and nine phthalate metabolites used as a proxy for prenatal exposure.
Br J Nutr
September 2025
Department of Human Nutrition, USA.
Age is the main risk factor for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. Despite our limited understanding of cellular mechanisms of aging-associated neuronal loss, an increasing number of studies demonstrate that oxidative stress and inflammation are key drivers. Epidemiological studies indicate that diet during middle adulthood can influence the risk of developing neurodegenerative diseases later in life, so it is important to investigate dietary interventions to combat oxidative stress and inflammation.
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