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Background And Objectives: Concerns remain regarding the safety of the retropubic tape (TVT) procedure. We assess the efficacy, satisfaction and long-term outcomes of the TVT procedure and compare it to the autologous fascial sling (AFS), colposuspension, and urethral bulking procedures.
Methods: A review of prospective data of all patients post stress urinary incontinence (SUI) surgery in our tertiary center between January 2012 and December 2020 was performed. Patients were invited to complete three validated questionnaires: International Consultation of Incontinence Modular Questionnaire Vaginal Symptoms (ICIQ-VS), ICIQ Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) and ICIQ satisfaction (ICIQ-S). Fisher's exact test was used to evaluate complications. Kruskal-Wallis test was used to evaluate satisfaction.
Key Findings: Eight hundred fifty-three SUI procedures were performed in the study period. The responses from 395 questionnaires were analyzed. Median follow up: 5.9 years (range 1-10.1). The TVT and AFS procedures were the most efficacious procedures: 64% TVT, 62% AFS, 40% Colposuspension, 26% urethral bulking, p < 0.001. The AFS group had the lowest reported rate of complications: 22.6% AFS, 65.7% TVT, 67.1% colposuspension, 71.74% Urethral bulking (p < 0.001). Pain was the most reported complication and the AFS group had the lowest reporting of severe pain: 68% AFS, 74% TVT, 80% Colposuspension, 78% urethral bulking (p = 0.350).
Limitations: Mesh exposure was not evaluated due to the lack of validated questionnaires.
Conclusion: The AFS and TVT procedures are reported as the most successful procedures for the surgical management of SUI. Due to the associated risk of mesh complications, we recommend AFS as the procedure of choice for the surgical management of SUI.
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http://dx.doi.org/10.1002/nau.70101 | DOI Listing |
Phytomedicine
August 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 102488, China. Electronic address:
Background: Diabetic nephropathy (DN), a serious diabetic complication, currently has limited treatment options. Yulan Jiangtang capsules (YL) are a clinically approved traditional Chinese medicine formula for glycemic control and diabetes-related complications. Nevertheless, the underlying mechanisms of their therapeutic effects remain incompletely elucidated.
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September 2025
Ultrasonography Department, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Quanzhou, 362200, China.
Renal ischemic disease represents a severe clinical pathological condition commonly observed in acute kidney injury (AKI), renal transplantation, and kidney surgery. It leads to renal tubular epithelial cell damage, inflammatory responses, and cell death, potentially progressing to chronic kidney disease (CKD) or even renal failure, significantly impairing patients' quality of life and survival rates. Current therapeutic strategies for renal ischemia-reperfusion injury (IRI) include pharmacological interventions, cell therapy, and gene therapy, yet their efficacy remains limited and may be accompanied by adverse effects.
View Article and Find Full Text PDFSci Adv
September 2025
Institut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, 75015 Paris, France.
Aminoglycosides (AGs) are broad-spectrum antibiotics effective against Gram-negative bacteria, with uptake dependent on membrane potential. However, the mechanisms of AG entry remain incompletely understood. Here, we identify a previously undescribed uptake pathway via carbohydrate transporters in .
View Article and Find Full Text PDFMol Biol Rep
September 2025
Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Aim: Ischemia-reperfusion (IR) injury-induced renal failure is a major cause of death and morbidity. Unfortunately, there is currently no proven protective therapy. The aim of the study is to investigate the protective effect of D-carvone against the renal ischemia-reperfusion (RIR) injury.
View Article and Find Full Text PDFCan J Urol
August 2025
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Benign prostatic hyperplasia (BPH) represents a prevalent etiology of lower urinary tract symptoms (LUTS) in the male population, clinically defined by a non-malignant proliferation of prostatic tissue. While BPH exhibits a high prevalence among older male populations globally, the precise underlying mechanisms contributing to its development remain incompletely elucidated. Mitochondria, essential organelles within eukaryotic cells, are critical for cellular bioenergetics, the regulation of reactive oxygen species (ROS) generation, and the modulation of cell death pathways.
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