Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Nutritional impairment is common among older adults with advanced cancer. The association between baseline nutritional impairment and the trajectory of quality of life (QOL) and psychological health among patients receiving palliative cancer treatment is not known.
Methods: We performed a secondary analysis of a nationwide clinical trial (NCT02107443; PI: Mohile, UG1CA189961). Adults aged 70 years with 1 impaired geriatric domain were enrolled (2014-2017). Nutritional impairment was defined as Mini Nutritional Assessment-Short Form score of 11. The Functional Assessment of Cancer Therapy-General (FACT-G, range 0-108) assessed QOL and the Geriatric Depression Scale-15 (GDS-15, range 0-15) assessed psychological health. We modeled group-based trajectories for FACT-G and GDS-15 via a discrete mixture model that identifies distinct subgroups with similar trajectories or patterns. After identifying distinct groups, we used multinomial logistic regression to assess the association of nutritional impairment with FACT-G and GDS-15 trajectory group membership.
Results: Among 479 patients, mean age was 77 (range 70-93) and 56% had nutritional impairment. We identified four QOL trajectories and four psychological health trajectories. Nutritional impairment was associated with group membership in Lowest (odds ratio [OR] 4.2, 95% confidence interval [CI] 2.0-8.9), Middle-Low (OR 3.8, 95% CI 2.1-6.9), and Middle-High QOL (OR 2.4, 95% CI 1.4-4.2), compared to Highest QOL. For depression, nutritional impairment was associated with membership in Worsening Mild Depression group (OR 3.7, 95% CI 1.8-7.5), compared to No Depression group.
Conclusions: Baseline nutritional impairment was independently associated with membership in every worse QOL trajectory group and with membership in the "Worsening Mild Depression" group. This is the first study, to our knowledge, to examine the association between baseline nutritional impairment and QOL and psychological health trajectory among patients with cancer. Integrating early nutritional assessment with paired supportive care is important for older adults with advanced cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236448 | PMC |
| http://dx.doi.org/10.1111/jgs.19617 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Muscle Mass Paradox: Elevated Lean Mass Indices Impair Systolic Function via Myocardial Remodeling in Obesity.
Echocardiography
September 2025
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Objectives: To explore the relationships between cardiac parameters and body composition indices, identifying predictors of subclinical cardiac systolic dysfunction.
Methods: Using anthropometric and serological parameters, echocardiography, and body composition analysis, this study evaluated metabolic profiles, cardiac remodeling patterns, and body composition characteristics in young adult obese patients, while quantifying the correlations between cardiac parameters and body composition indices. Subclinical left ventricular systolic dysfunction was defined as global longitudinal strain (GLS) < 18%.
Determining the appropriate soybean meal inclusion level in lactation diets for sows endemically infected with porcine reproductive and respiratory syndrome virus (PRRSv).
Transl Anim Sci
May 2025
Carthage Veterinary Service Ltd., Carthage, IL 62321, USA.
Soybean meal (SBM) contains many bioactive compounds, such as isoflavones, which possess anti-inflammatory and anti-oxidative properties that may provide nutritional intervention to pigs infected with porcine reproductive and respiratory syndrome virus (PRRSv). The disease results in abortions, stillborn piglets, and overall impairs reproductive success in sows. Today, there are no data available on feeding SBM to sows infected with PRRSv to mitigate the negative impacts of PRRSv on sow and litter performance.
View Article and Find Full Text PDFApolipoprotein E4 allele, antibodies against periodontal microorganisms, and cognition in older adults.
J Alzheimers Dis Rep
September 2025
Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Background: The presence of the apolipoprotein E4 () allele and periodontal disease are independently correlated with higher levels of amyloid-β and inflammation in the brain, worse cognition, and Alzheimer's disease.
Objective: To assess whether the presence of the allele modifies the relationship between IgG antibodies against periodontal microorganisms and cognitive function in older adults participating in the NHANES III study.
Methods: This cross-sectional analysis was conducted among participants of the third National Health and Nutrition Examination Survey (NHANES III) (1988 to 1994), aged 60 years and older, with measurements of IgG antibodies against 19 periodontal microorganisms and alleles (N = 1644).
Research advances in SERS-based sensing platforms for multiplex mycotoxin detection in feed.
Nanoscale Adv
September 2025
State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences Beijing 100193 China
Mycotoxins in feed can pose significant risks to the health of livestock and poultry, leading to reduced economic returns and impaired production efficiency, thereby impeding the sustainable development of the livestock industry. Consequently, the exploration of highly sensitive, simple and rapid detection methods for trace mycotoxins in feed is crucial for ensuring feed safety and promoting industrial sustainability. Surface-enhanced Raman spectroscopy (SERS), a rapid detection method characterized by high sensitivity, ease of operation, and resistance to water interference, has gained substantial traction in mycotoxin detection within feed matrices in recent years.
View Article and Find Full Text PDFHealthcare professionals' perspectives on the current state of obesity management training: A mix methods study.
Obes Pillars
December 2025
Conway Institute, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Introduction: Obesity is a disease that represents a major global health problem, affecting over a quarter of European adults and straining healthcare systems. Despite its multifactorial causes, many healthcare professionals lack adequate training and confidence in delivering effective, person-centered obesity care. Weight stigma and misconceptions further impair outcomes.
View Article and Find Full Text PDF