Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The design and preparation of particulate drug delivery systems are crucial for enhancing drug efficacy and reducing adverse effects. Spray drying has emerged as a versatile technique for tailoring the particle size, morphology, encapsulation efficiency and release kinetics of drug-loaded particles. This review provides a comprehensive overview of spray drying processes used in the design and fabrication of particulate drug delivery systems. It offers an in-depth analysis of spray drying for modulating the physicochemical properties and performance of drug-loaded particles, as well as its updated applications in various pharmaceutical formulations. Furthermore, the review discusses the different processing parameters of this technique and their effects on drug-loaded particles properties, along with emerging applications in the delivery of biologics and advancements in equipment technology. The objective of this review is to provide researchers with a valuable resource and guide for the recent development and evaluation of spray dried drug-loaded particles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2025.125917 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Synthesis of a temperature-responsive multimodal motion microrobot capable of precise navigation for targeted controllable drug release].
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Objectives: To synthesize a temperature-responsive multimodal motion microrobot (MMMR) using temperature and magnetic field-assisted microfluidic droplet technology to achieve targeted drug delivery and controlled drug release.
Methods: Microfluidic droplet technology was utilized to synthesize the MMMR by mixing gelatin with magnetic microparticles. The microrobot possessed a magnetic anisotropy structure to allow its navigation and targeted drug release by controlling the temperature field and magnetic field.
Redox-triggered hyaluronic acid polymersomes for co-delivery of methotrexate and curcumin to breast cancer cells.
Int J Biol Macromol
August 2025
Department of Biomedical Engineering, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
Among nanoparticles, polymersomes have drawn notable interest due to their ability to simultaneously load two drugs, their suitable size, high stability, and controlled drug release. In this study, an amphiphilic, redox-sensitive hyaluronic acid-polycaprolactone block copolymer was synthesized for targeted drug delivery to CD44-overexpressing breast cancer MDA-MB-231 cells. Nanopolymersomes were formed via nanoprecipitation and co-loaded with curcumin and methotrexate.
View Article and Find Full Text PDFBioengineered nanocomposite bacitracin zinc-loaded chitosan microspheres containing keratin/gelatine films for wound healing.
J Drug Target
September 2025
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India.
This study sought to create and characterize a novel antibiotic-loaded keratin-based film bandage for enhanced wound healing. Using the solvent casting method, keratin from chicken feathers was combined with gelatin (KG) in varying ratios to form films. Chitosan microspheres (Mc) were incorporated to achieve sustained release of bacitracin zinc (BZ).
View Article and Find Full Text PDFSmart wound management with sustainable pH sensing and dynamic electrotherapy.
Acta Biomater
August 2025
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China; Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031,
Smart wound management remains a significant challenge, necessitating real-time monitoring and dynamic treatment. Herein, an innovative multifunctional Janus dressing is designed to enable sustainable pH sensing, and provide dynamic drug delivery and electrical therapy at infected wounds. Specifically, the hydrophilic side is a pH-sensing layer with phenol red grafted onto amino-modified poly (2-hydroxyethyl methacrylate) via Mannich reaction, while the hydrophobic side contains drug-loaded piezoelectric particles semi-embedded in a polydimethylsiloxane matrix for therapeutic delivery.
View Article and Find Full Text PDFNovel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer.
Eur J Pharm Biopharm
October 2025
Leicester School of Pharmacy, De Montfort University, Leicester, United Kingdom; Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, United Kingdom. Electronic address:
Different strategies and multifunctional nano-carriers have been employed to enhance chemotherapeutic drugs bioavailability and tackle acquired multi-drug resistance (MDR) thus ensuring efficient chemotherapy with fewer adverse effects. Among these, mesoporous Silica Nanoparticles (MSNs) are exciting matrices for improving cytotoxic drugs bioavailability and circumventing MDR through its potential of co-delivery of anticancer agents and short interfering RNA (siRNA). In this study, MSNs were coated with (1:1) Polyethyleneimine (PEI) and phospholipids (PL) composite and were loaded with KAZ3 (Anticancer chalcone) using coaxial electrospraying in a one step process.
View Article and Find Full Text PDF