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Clear aligners have transformed orthodontic treatment; however, they exhibit limited effectiveness in closing extraction spaces due to cumulative movement errors and excessive tipping. This proof-of-concept study introduces an innovative multi-step finite element method (FEM) for simulating sequential clear aligner applications in extraction space closure. A compensation protocol, incorporating an adaptive iterative FEM, was compared with a conventional protocol, and movement precision and unintended tipping were analyzed. The results demonstrated that the compensation protocol significantly reduced tipping (≤ 1°) compared to the conventional approach (> 6°) and minimized the mismatch between crown and root movements. Additionally, the compensation protocol consistently maintained a high achievement rate, preventing the progressive loss of movement efficiency typically observed with conventional protocols. It also provided a more controlled vertical displacement, thereby reducing unwanted extrusion. Furthermore, synchronized crown-root movement contributed to more stable bodily movement, ensuring that teeth followed the intended trajectory more accurately. These findings highlight the potential of the compensation protocol in improving treatment predictability and accuracy in extraction cases. This approach enables systematic adjustment of aligner design based on actual tooth movement, offering an optimized strategy for clear aligner biomechanics and potentially enhancing clinical outcomes in orthodontic treatment.
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http://dx.doi.org/10.1038/s41598-025-07110-6 | DOI Listing |
Diabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
View Article and Find Full Text PDFJ Neurol
September 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: The "Systematic Screening of Handwriting Difficulties in Parkinson's Disease" (SOS) test is the only tool specifically designed to evaluate handwriting in people with Parkinson's Disease (pwPD). It is language specific.
Objective: To assess the construct validity, intrarater and interrater reliability of the Italian version of the SOS test.
Chem Rec
September 2025
School of Physics and Mechanics, Wuhan University of Technology, Wuhan, 430070, Hubei, P. R. China.
The development of sensors for monitoring breath acetone, a key biomarker for ketosis in diabetes mellitus, represents a critical frontier in medical diagnostics, promising a painless alternative to invasive blood tests. This review provides a comprehensive and critical evaluation of the state-of-the-art in acetone gas sensing technologies, including chemiresistive, optical, electrochemical, conductometric, and microwave platforms. We focus specifically on recent breakthroughs driven by advanced materials, analyzing how novel nanostructures from two-dimensional (2D) materials such as MXenes to porous metal-organic frameworks (MOFs) are engineered to push performance to clinically relevant parts-per-billion (ppb) sensitivity.
View Article and Find Full Text PDFLancet Oncol
September 2025
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Select patients with metastatic clear-cell renal-cell carcinoma can be treated without systemic therapy, yet few studies have explored this population. We investigated the efficacy of metastasis-directed therapy without systemic therapy in oligometastatic clear-cell renal-cell carincoma.
Methods: This investigator-initiated single-arm, phase 2 trial enrolled patients aged 18 years or older with an Eastern Cooperative Oncology Group performance status of 0-2, histologically confirmed clear-cell renal-cell carcinoma, and one to five metastases.
J Cardiovasc Magn Reson
September 2025
Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK. Electronic address:
Background: Cardiac diffusion tensor imaging (cDTI) is sensitive to imaging parameters including the number of unique diffusion encoding directions (ND) and number of repetitions (NR; analogous to number of signal averages or NSA). However, there is no clear guidance for optimising these parameters in the clinical setting.
Methods: Spin echo cDTI data with 2 order motion compensated diffusion encoding gradients were acquired in ten healthy volunteers on a 3T MRI scanner with different diffusion encoding schemes in pseudo-randomised order.