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Open access publishing: is urology ready? A survey of authors, readers, and editorial board's knowledge, impressions and satisfaction.
World J Urol
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Division of Urology, University of Montreal Hospital Centre, Montreal, QC, Canada.
Purpose: To report the level of knowledge, impressions, and satisfaction of Urology readers, authors, and editorial boards regarding Open Access (OA) publishing in the field of Urology and to determine their satisfaction with the current OA models.
Methods: We developed an online, five-section cross-sectional survey including 23 questions. To recruit participants, we used mixed methods to obtain responses based on a simple random sampling and convenience sampling.
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Department of Clinical Research and Leadership, PhD Program in Translational Health Sciences, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
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Cancer Lett
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Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address:
Dendritic cells (DCs) are the most powerful antigen-presenting cells (APCs) within the tumour microenvironment (TME), where they orchestrate T cell-mediated anti-tumour immunity and can also be reprogrammed to promote the progression of tumours in the TME. Extracellular vesicles (EVs) are very small and they are secreted by cells and wrapped in lipid bilayers that shuttle bioactive cargoes, including proteins, nucleic acids, and metabolites, to recipient cells, thereby influencing the progression of diseases, including cancer. DC-derived EVs (DC-EVs) play pivotal roles in the TME by mediating crosstalk with other immune and stromal cells to modulate inflammatory responses, angiogenesis, cell death, and immune evasion, thereby regulating the development and progression of tumours.
View Article and Find Full Text PDFAssociation of the PWWP-domain protein HUA2 and the H3K36 methylation in flowering time control.
Plant J
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Université de Strasbourg, CNRS, IBMP UPR 2357, Strasbourg, France.
Trimethylation of histone H3 at lys36 (H3K36me3) promotes gene transcription and governs plant development and plant responses to environmental cues. Yet, how H3K36me3 is translated into specific downstream events remains largely uninvestigated. Here, we report that the Arabidopsis PWWP-domain protein HUA2 binds methyl-H3K36 in a PWWP motif-dependent manner.
View Article and Find Full Text PDFThe Hypoxia-Induced Chromatin Reader ZMYND8 Drives HIF-Dependent Metabolic Rewiring in Breast Cancer.
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Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400094, India. Electronic address:
Breast cancer, a leading cause of mortality, exhibits significant heterogeneity across molecular subtypes, with tumor hypoxia contributing to poor therapeutic outcomes. The present study investigates the role of ZMYND8, a hypoxia-responsive epigenetic factor, in regulating carbohydrate metabolism in concert with HIF1α in breast cancer. In adherent cells as well as in 3D MCTS, ZMYND8 expression is elevated under hypoxic conditions.
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