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Objectives: This paper describes how artificial intelligence (AI) was used to analyze meeting minutes from community coalitions participating in the HEALing Communities Study. We examined how often coalitions discussed stigma when selecting evidence-based practices (EBPs), variations in stigma-related discussions across coalitions, how these discussions addressed race, ethnicity, and racial inequity, and whether the frequency of stigma discussions was associated with the proportion of minoritized populations in each community.
Methods: We used Natural Language Processing, Machine Learning, and Large Language Models, employing ChatGPT Enterprise to code data, ensuring data security and privacy compliance with the General Data Protection Regulation and HIPAA.
Results: Community coalitions varied in the extent to which they discussed stigma during meetings focused on EBPs to reduce overdose deaths. Stigma was mentioned more frequently in the context of medication for opioid use disorder compared with other EBPs. As the percentage of racial/ethnic minority populations increased in a county, so did the strength of the association between discussions of EBPs and stigma. Counties with a greater proportion of racial/ethnic minority populations were more likely to integrate discussions of EBPs with stigma-related issues. Specifically, discussions about stigma were ~57% more likely to occur when racial or ethnic disparities were mentioned, compared with when they were not (odds ratio=1.57; 95% CI: 1.22, 2.03).
Conclusions: The paper highlights the potential for integrating AI-human collaboration into community-engaged research, particularly in leveraging qualitative data such as meeting minutes. It shows how AI can be used in real-time to enhance community-based research.
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http://dx.doi.org/10.1097/ADM.0000000000001534 | DOI Listing |
Alzheimers Dement
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Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non-invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular alterations. By synthesizing interdisciplinary evidence, we identify retinal biomarkers as promising tools for early diagnosis and risk stratification.
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August 2025
Department of Ophthalmology, Stanford University, Palo Alto, CA, United States.
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Dept of Histopathology, PGIMER, Chandigarh, 160012, India.
Artificial intelligence (AI) is a technique or tool to simulate or emulate human "intelligence." Precision medicine or precision histology refers to the subpopulation-tailored diagnosis, therapeutics, and management of diseases with its sociocultural, behavioral, genomic, transcriptomic, and pharmaco-omic implications. The modern decade experiences a quantum leap in AI-based models in various aspects of daily routines including practice of precision medicine and histology.
View Article and Find Full Text PDFResearch (Wash D C)
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NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan 571199, China.
Aging is characterized by a gradual decline in the functionality of all the organs and tissues, leading to various diseases. As the global population ages, the urgency to develop effective anti-aging strategies becomes increasingly critical due to the growing severity of associated health problems. Immunotherapy offers novel and promising approaches to combat aging by utilizing approaches including vaccines, antibodies, and cytokines to target specific aging-related molecules and pathways.
View Article and Find Full Text PDFiScience
September 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity. Moreover, most algorithms lack rigorous iterative evaluation, a crucial aspect of protein engineering exemplified by classical directed evolution. This study introduces DeepDE, a robust iterative deep learning-guided algorithm leveraging triple mutants as building blocks and a compact library of ∼1,000 mutants for training.
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