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Background: To assess cardiorespiratory efficiency in obese adults, two exercise test treadmill protocols with 2- or 3-minute stages were compared.
Methods: Thirty-six obese adult subjects were involved in this study. Sixteen men (age 51.5±10.5 years; body mass index [BMI] 36.7±4.8 kg/m) and 20 women (age 42.4±12.4 years; BMI 36.5±4.7 kg/m) performed submaximal incremental graded tests on treadmills with 2- or 3-minute stages on different days. During each testing session, heart rate (HR), oxygen uptake (VO mL/min/kg), rate of perceived exertion (RPE), fat oxidation (FO) at maximal fat oxidation (MFO), and maximal fat oxidation zone (Fatmax zone) were measured.
Results: No differences were found for HR, VO, and RPE at MFO between the two protocols. Significant differences (2-minute vs. 3-minute) were found for FO (576.3±162.9 mg/min vs. 506.0±148.1 mg/min respectively; <0.05) at MFO between the two protocols. No differences were found for VO and HR in high and low Fat zone borders. Moreover, a difference was found for FO at the low and high borders.
Conclusion: Exercise intensity at which the MFO and Fat zone occur is not influenced by the duration of stage-to-stage increments. The two exercise testing protocols could be considered interchangeable to assess HR, VO, and RPE at MFO.
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http://dx.doi.org/10.7570/jomes24049 | DOI Listing |
J Hepatol
September 2025
National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa, Italy. Electronic address:
Cell Metab
August 2025
Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA. Electronic address:
Diet and obesity contribute to insulin resistance and type 2 diabetes, in part via the gut microbiome. To explore the role of gut-derived metabolites in this process, we assessed portal/peripheral blood metabolites in mice with different risks of obesity/diabetes, challenged with a high-fat diet (HFD) + antibiotics. In diabetes/obesity-prone C57BL/6J mice, 111 metabolites were portally enriched and 74 were peripherally enriched, many of which differed in metabolic-syndrome-resistant 129S1/129S6 mice.
View Article and Find Full Text PDFPhytomedicine
August 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, 102488, China. Electronic address:
Background: Diabetic nephropathy (DN), a serious diabetic complication, currently has limited treatment options. Yulan Jiangtang capsules (YL) are a clinically approved traditional Chinese medicine formula for glycemic control and diabetes-related complications. Nevertheless, the underlying mechanisms of their therapeutic effects remain incompletely elucidated.
View Article and Find Full Text PDFCell Rep
September 2025
Department of Pathology, University of Iowa, Iowa City, IA, USA. Electronic address:
High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
September 2025
Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília, SP, 17525-902, Brazil.
The symbiosis between intestinal bacteria and the human body's physiological processes can modulate health. The intestinal microbiota is linked to the development of neurotrophic factors; therefore, it is increasingly related to the modulation of nervous system pathologies. Moreover, microbiota can interfere with inflammation and oxidative stress, which are closely linked to cardiovascular risk factors and several other inflammatory conditions, such as kidney and neurodegenerative diseases.
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