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In hydrogen-based membrane biofilm reactors (H-MBfR), the most critical concerns revolve removal rate and membrane fouling. This study introduces a novel flat membrane module to enhance denitrification efficiency and the operational stability of MBfR. The membrane module featured an additional layer of polyester material on outer side of the membrane. Experimental results demonstrated that membrane fouling occurred after one week, while the flocking layer extended the fouling-free operation to over eight weeks, representing an eightfold improvement at least. Low temperature and high loading were observed to impact the denitrification efficiency, although it maintained around 50 % without nitrite accumulation. Following the removal of operational disturbances, the MBfR rapidly restored with removal efficiencies reaching 93.8 % to 100 %. As the MBfR operated, microbial analysis revealed a decrease in microbial diversity, and differential expression levels of denitrification genes. The novel membrane module contributed to improving fouling control and removal flux.
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http://dx.doi.org/10.1016/j.biortech.2025.132848 | DOI Listing |
J Integr Plant Biol
September 2025
State Key Laboratory of Plant Environmental Resilience, Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
In higher plants, stomatal movements represent a critical physiological process that matains cellular water homestasis while enabling photosynthetic gas exchange. Open stomata 1 (OST1), a key protein kinase in the abscisic acid (ABA) signaling cascade, has been established as a central regulator of stomatal dynamics. This study reveals that two highly conserved mitogen-activated protein kinase 1 (MAP4K1) and MAP4K2 are positive regulators in ABA promoted stomatal closure, and ABA-activated OST1 potentiates MAP4K1/2 through phosphorylation at conserved serine and threonine residues (S166, T170, and S479/S488).
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China.
To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using confocal microscopy with the HRT II Rostock Corneal Module. We reported a 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history of gradual-onset blurred vision. Slit-lamp examination revealed yellowish deposits in the corneal endothelium and Descemet's membrane.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Faculty of Health Sciences, University of Macau, Macau SAR 999999, China.
Breast cancer is a global health challenge necessitating more precise and effective treatment strategies. In this study, we developed a novel drug-loaded therapeutic nanoplatform, OCPdots@CTe, which integrated near-infrared-II (NIR-II) window phototheranostic for targeted treatment of orthotopic breast tumors. The outer membrane vesicles (OMVs) can stimulate more immune responses based on precise targeting, while chelerythrine (CTe) can induce apoptosis by generating reactive oxygen species (ROS), thereby enhancing the therapeutic effect.
View Article and Find Full Text PDFPlant Commun
September 2025
State Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang 455000, Henan, China; Xinjiang Key Laboratory for Crop Gene Editing and Germplasm Innovation, Institute of Western Agricultural of CAAS, Changji, 831
Cotton fiber length, a key determinant of its industrial utility, is one of the most important agricultural traits subjected to domestication. However, the genetic determinants and molecular mechanisms underlying natural variation in fiber length remain inadequately characterized. We identified GhTTL as a critical positive regulator of fiber elongation through genome-wide association analysis (GWAS).
View Article and Find Full Text PDFAnal Chim Acta
October 2025
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. Electronic address:
Background: The dynamic interplay between esterase activity and physicochemical microenvironments-such as polarity and viscosity-is critical for decoding early cellular dysfunction in processes like apoptosis, ferroptosis, and drug-induced toxicity. However, conventional probes typically report only a single parameter, obscuring interdependent changes in enzyme activity and membrane properties. This technological gap limits our ability to capture real-time, spatially resolved fluctuations within subcellular compartments.
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