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http://dx.doi.org/10.1164/rccm.202502-0467RL | DOI Listing |
J Orthop Res
September 2025
Faulty of Applied Science and Engineering, University of Toronto, Toronto, Canada.
Proper alignment between donor and recipient cartilage in osteochondral allograft transplantation supports tissue integration and the formation of a stable articulating surface. This study evaluated the use of patient-specific 3D-printed drill guides to improve alignment in an ovine model of osteochondral allograft transplantation when used in place of a free-hand drilling technique. Fourteen female Arcott sheep underwent bilateral osteochondral allograft transplantation.
View Article and Find Full Text PDFActa Neurochir (Wien)
September 2025
Faculty of Medicine, The University of Queensland, Herston, QLD, 4006, Australia.
Background: Identifying haemodynamic factors associated with thin-walled regions (TWRs) of intracranial aneurysms is critical for improving pre-surgical rupture risk assessment. Intraoperatively, these regions are visually distinguished by a red, translucent appearance and are considered highly rupture prone. However, current imaging modalities lack the resolution to detect such vulnerable areas preoperatively.
View Article and Find Full Text PDFVet Surg
September 2025
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Objective: To determine if a novel robotic system has comparable positional and angular accuracy to that achievable with patient-specific guides (PSG) when used for transcondylar screw (TCS) placement in the canine humerus.
Study Design: Experimental laboratory study.
Sample Population: A total of 32 synthetic humeral models (16 per group).
Sci Adv
September 2025
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images.
View Article and Find Full Text PDFCurr Gene Ther
August 2025
Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Lucknow, Uttar Pradesh, India.
Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract, presents significant challenges in clinical medicine due to its multifactorial etiology and varied therapeutic responses. This review examines the diverse causes of CD, including genetic predispositions identified through genome-wide association studies (GWAS), which involve scanning the genome for single-nucleotide polymorphisms associated with CD risk, as well as environmental triggers, such as diet and alterations in the microbiome. Biomarkers, such as fecal calprotectin and Creactive protein (CRP), as well as genetic markers like NOD2 mutations, provide critical tools for diagnosis and treatment stratification.
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