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http://dx.doi.org/10.1093/europace/euaf102 | DOI Listing |
Europace
June 2025
Cardiac Arrhythmia Center, Division of Cardiology at Montefiore-Einstein Center, Albert Einstein College of Medicine, 111 East 210 Street, Bronx, NY, USA.
Thorax
June 2025
Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Background: The association between lower adult lung function and increased cardiovascular comorbidity has not been adequately explained. We investigated whether shared developmental signalling pathways, critical to lung development and repair, could partly explain it.
Methods: In UK Biobank (UKB), we performed pairwise colocalisation analysis of variants in 55 lung development genes associated with adult forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV)/FVC, to see if these are also associated with coronary heart disease (CHD), blood pressure (systolic, diastolic, hypertension), pulse pressure, Arterial Stiffness index and carotid intima-media thickness.
Biol Trace Elem Res
April 2025
Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Osteoarthritis (OA) is one of the most prevalent chronic diseases of the aging population, with an incidence of more than 250 million affected people and annual treatment costs exceeding $80 billion. Osteoarthritis involves pain, stiffness, reduced mobility, and swelling of the joints due to cartilage wear and tear and inflammation, which results in a broad system affecting the joints. This review focuses on the relationship between zinc and copper and the effects of these minerals on osteoarthritis.
View Article and Find Full Text PDFPLoS One
April 2025
State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
The arch of the human foot plays a significant role in bearing weight and keeping gait balance. Previous studies mainly focus on the foot arch stiffness at the static or quasi-dynamic state of a particular foot shape. The variation of the linear arch stiffness across the entire walking gait has rarely been reported.
View Article and Find Full Text PDFJ Am Chem Soc
April 2025
School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, P.R. China.
Controlled liquid-liquid phase separation (LLPS) plays an important role in the formation of a heterogeneously structured extracellular matrix (ECM) consisting of densely cross-linked stiff structures compartmentalized in a loosely cross-linked matrix. Moreover, the mechanical cues presented by the cellular-scale structural heterogeneity of the ECM facilitate the mechanotransduction of cells and subsequent cellular development. Therefore, developing ECM-mimetic hydrogels with compartmentalized structural heterogeneity as inductive cell carriers is highly desirable but challenging.
View Article and Find Full Text PDF