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http://dx.doi.org/10.1007/s12035-025-05134-7 | DOI Listing |
Genome Med
August 2025
Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, 308433, Singapore.
Int Immunopharmacol
August 2025
Hebei Key Laboratory of Research and Development for Chinese Medicine, Chengde Medical University, Hebei, Chengde 067000, China. Electronic address:
Neuropathic pain (NP) is increasingly recognized as a chronic stressor contributing to the development of depressive comorbidities through neuroimmune dysregulation. However, the mechanistic interplay between microglial polarization states and kynurenine pathway (KP) metabolism in this process remains incompletely understood. The present study investigated the therapeutic potential of paeoniflorin (PF), a bioactive monoterpene glycoside, in alleviating NP-associated depression by modulating the M1 microglial M1 polarization-kynurenine 3-monooxygenase (KMO) pathway.
View Article and Find Full Text PDFJ Alzheimers Dis
August 2025
Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA.
BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, amyloid plaques, neurofibrillary tangles, and neuroinflammation. Glial cells-astrocytes, microglia, and oligodendrocytes-play essential roles in AD progression, but their pathway-specific genetic contributions remain unclear.ObjectiveTo identify glial cell type-specific biological pathways associated with AD using pathway-based polygenic risk score (PRS) analysis.
View Article and Find Full Text PDFNature
August 2025
Institute for Stem Cell Biology and Regenerative Medicine, Department of Pathology, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Migration of transplanted allogeneic myeloid cells into the brain following systemic hematopoietic stem and progenitor cells transplantation (HCT) holds great promise as a therapeutic modality to correct genetic deficiencies in the brain such as lysosomal storage diseases. However, the toxic myeloablation required for allogeneic HCT can cause serious, life-threatening side effects limiting its applicability. Moreover, transplanted allogeneic myeloid cells are highly vulnerable to rejection even in an immune-privileged organ like the brain.
View Article and Find Full Text PDFSeizure
August 2025
University of Wisconsin-Madison, Department of Neurology, United States. Electronic address:
Purpose: Approximately one-third of patients with epilepsy become refractory to traditional anti-seizure medications. Evidence from animals and in humans suggests a bidirectional relationship between epilepsy and neuroinflammation, offering potential as a novel therapeutic pathway. This study investigates region-specific relationships between neuroinflammation and medication-refractory focal epilepsy using [F]FEPPA, a next-generation translocator protein radioligand and biomarker for microglial density with favorable binding kinetics and signal-to-noise ratio compared to [C]PK11195.
View Article and Find Full Text PDF