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Article Abstract
An R-loop is a complex nucleic acid structure consisting of an RNA-DNA hybrid and an associated single-stranded DNA. This structure plays an important role in many biological processes, including gene regulation, DNA replication, and maintenance of genome stability. Under physiological conditions, the R-loop is in a dynamic balance of generation and decomposition, which is a complex process involving multiple mechanisms of its formation, clearance, and regulation. Emerging evidence indicates that R-loops can drive inflammation and participate in immune processes. This review summarizes immune dysregulation resulting from impaired R-loop clearance and analyzes recent advances in computational methods for R-loop regulation, aiming to identify new avenues for developing R-loop-targeted immunotherapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173303 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000042833 | DOI Listing |
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