Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The development of effective drug delivery strategy by employing novel nano-careers are advantageous for targeted and controlled drug release. The present work describes about such a strategy in the form of a protein stabilized ultrasmall gold nanocluster as nano-career for the delivery of anticancer drug Gemcitabine (Gem). Gold nanocluster (AuNCs) stabilized by bovine serum albumin (BSA) was synthesized and characterized in detail including its stability, size distribution, toxicity, and photo-physical properties. It was revealed that monodispersed gold particles (~ 1.5 nm) dispersible in aqueous phase with unique optical absorption and emission characteristics (λabs = 450 nm, λemi = 650 nm), high stability and minimum toxicity was obtained. Afterward, an anticancer drug (Gem) was conjugated with the gold cluster through simple chemical mixing resulting in the formation of 55% drug load Au nanocluster (Gem-AuNCs-BSA). The resultant Gem-AuNCs-BSA showed enhanced delivery of drug and therapeutic effects for the treatment of breast cancer and lung cancer with better efficacy than free Gemcitabine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12032-025-02810-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of an AMBER-Compatible Force Field for Gold Nanoclusters Protected by -Heterocyclic Carbenes.
J Chem Theory Comput
September 2025
Department of Physics, Nanoscience Center, University of Jyväskylä, Jyväskylä FI 40014, Finland.
-Heterocyclic carbene (NHC)-protected gold nanoclusters (AuNCs) have emerged as promising candidates for biomedical applications due to their high stability and strong photoluminescence. However, their integration into atomistic molecular dynamics (MD) simulations, which facilitates an understanding of their behavior in biological environments, has been hindered by the lack of reliable force field parameters. Here, we present a new set of parameters for classical MD simulations of NHC-protected AuNCs, fully compatible with the AMBER force field.
View Article and Find Full Text PDFRational Design and Applications of Ultrasmall Gold Nanoparticles.
Top Curr Chem (Cham)
September 2025
Center for Advanced Materials Research, Research Institute of Sciences and Engineering, University of Sharjah, 27272, Sharjah, United Arab Emirates.
Controlling the size of gold nanoparticles (AuNPs) has been critical in diagnostics, biomolecular sensing, targeted therapy, wastewater treatment, catalysis, and sensing applications. Ultrasmall AuNPs (uAuNPs), with sizes Ranging from 2 to 5 nm, and gold nanoclusters (AuNCs), with sizes less than 2 nm, are often dealt with interchangeably in the literature, making it challenging to review them separately. Although they are grouped in our discussion, their chemical and physical properties differ significantly, partly due to their electronic properties.
View Article and Find Full Text PDFDual-Shell-Solidified Gold Nanoclusters-Based Electrochemiluminescence Sensing Platform for Highly Selective and Sensitive Detection of Cu and Histidine.
ACS Appl Mater Interfaces
September 2025
School of Biomedical Engineering, Shenzhen Key Laboratory for Nano-Biosensing Technology, Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
Electrochemiluminescence (ECL) is rapidly emerging as an excellent electrochemical analytical technique for the specific and sensitive detection of various biomarkers and hazardous trace metals. Among ECL emitters, gold nanoclusters (AuNCs) have proven to be excellent luminophores due to their remarkable luminescent properties, stability, and biocompatibility. However, the low ECL efficiency of AuNCs precludes their application in ultrasensitive biosensing.
View Article and Find Full Text PDFFunctionalization of Gold-Pincer Nanocluster for Asymmetric Catalysis.
J Am Chem Soc
September 2025
Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China.
Organic ligand-protected metal nanoclusters feature ultrasmall size, well-defined compositions, and diverse chiral structures. They have the potential to combine the advantages of asymmetric organocatalysis and nanometal catalysis. The major challenge is designing and synthesizing appropriate metal nanocluster structures for achieving high catalytic activity and excellent enantioselectivity.
View Article and Find Full Text PDFNanobubbles: An emerging therapeutic paradigm for targeted cancer therapy.
Bioorg Chem
August 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran. Electronic address:
Recently, nanobubbles (NBs) have emerged as a groundbreaking platform for drug and gene delivery in the targeted treatment of cancer because of their unique advantages. The nanoscale dimensions, stability, and responsiveness to external triggers-for example, ultrasound-allow for highly selective localization and controlled release of therapeutic agents in tumor tissues. This review highlights the capability of NBs, when combined with ultrasound activation, to significantly improve the intracellular uptake, penetration, and therapeutic efficacy of chemotherapeutic agents, thus diminishing their off-target toxicity.
View Article and Find Full Text PDF