Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Salivary gland cancers are rare, diverse malignancies characterized by poor response to immunotherapy. The tumor immune environment in these cancers remains poorly understood. To address this, we perform an integrative analysis of the tumor immune microenvironment in a large cohort of advanced salivary gland cancer samples. Most tumors exhibit low immune activity with limited immune cell infiltration. Inflammation is linked to higher tumor mutational burden in non-adenoid cystic carcinoma histologies. Subtype specific expression of immune checkpoints is identified with prominent expression of VTCN1 in luminal-like cells within adenoid cystic carcinoma. Macrophages with immunosuppressive properties dominate the immune microenvironment across subtypes. Responses to immunotherapy are limited and associated with a higher ratio of T-cells relative to macrophages in individual cases, warranting further investigation. Here, we show an immunosuppressive environment in salivary gland cancers and identify subtype-specific immune vulnerabilities that could inform tailored therapeutic strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162891 | PMC |
| http://dx.doi.org/10.1038/s41467-025-60421-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Myoepithelial Carcinoma Ex-Pleomorphic Adenoma Exposing a RET Germline Mutation: A Rare Genetic Event.
Head Neck Pathol
September 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Myoepithelial carcinoma (MECA) is a malignant neoplasm composed exclusively of myoepithelial cells and accounts for less than 1% of all salivary gland tumors. Its diagnosis is often challenging due to histologic overlaps with benign lesions and its variable morphologic presentation. Although molecular profiling has emerged as a valuable tool in salivary gland tumor classification, the genetic landscape of MECA remains incompletely defined.
View Article and Find Full Text PDFThe Complex Roles of Macrophages in Sjögren's Syndrome: A Narrative Review.
Cureus
August 2025
Department of Hepatology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, CHN.
Sjögren's syndrome (SS) is an autoimmune disease characterized by the destruction of the structure and function of exocrine glands (EGs) such as lacrimal glands (LGs) and salivary glands (SGs). During the pathogenesis, various immune cells such as lymphocytes, dendritic cells, and macrophages are activated, which together maintain the pro-inflammatory environment of the EGs. As an important immune cell linking innate and specific immunity, macrophages have both functions of phagocytosis and antigen presentation.
View Article and Find Full Text PDFReduced circulating regulatory T cells in primary Sjögren's syndrome: the contribution of enhanced apoptosis and impaired survival.
Front Immunol
September 2025
Division of Rheumatology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Background: Regulatory T cells (Tregs) are found to be critical for maintaining immune tolerance to self-antigens; however, their status in primary Sjögren's syndrome (pSS) remains unclear. We investigated alterations in the abundance of peripheral Tregs in a large pSS cohort and their implications for patients.
Methods: Levels of CD4+CD25+FOXP3+Treg cells in the peripheral blood of 624 patients with pSS, and 93 healthy controls (HCs) were detected using modified flow cytometry (FCM).
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Mater Today Bio
October 2025
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan, 250021, Shandong, China.
Adenoid cystic carcinoma (ACC) is a lethal salivary gland malignant neoplasm. Lung metastasis is the primary cause of mortality in ACC patients while there is no effective treatment available at present. In this study, a precise and biomimetic nanoplatform, CG/MC/U-M, is designed to combine cuproptosis, gas therapy and immunotherapy against metastatic adenoid cystic carcinoma.
View Article and Find Full Text PDFPost-viral alterations in periodontal health in individuals recovering from COVID-19.
Front Oral Health
August 2025
Department of Periodontology, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.
This study explores post-viral immune modulation in periodontal health using COVID-19 convalescence as a model. We hypothesized that post-COVID-19 recovery induces epigenetic alterations, measurable through salivary methyl-transferase-like 3 (METTL3) expression and clinical-periodontal parameters. The present research comprises results from two studies: the clinical study, which included a total of 83 systemically healthy adults stratified into four groups according to periodontal status and COVID-19 history, and the laboratory study on human parotid gland samples ( = 10).
View Article and Find Full Text PDF