The role of adjuvant radiotherapy in relation to tumor size for bone-invasive pT4aN0 oral squamous cell carcinoma - A retrospective observational matched cohort study.

Objective: Oral squamous cell carcinoma (OSCC) with bone invasion are staged as pT4a, potentially upstaging smaller tumors. This study aimed to evaluate the oncological benefit of postoperative radiotherapy (PORT) in pT4aN0 OSCC with respect to tumor size and without other risk factors.

Methods: This retrospective matched cohort study included pT4aN0 OSCC patients with bone invasion treated surgically (R0) between 2010 and 2022.

Epidemiological and Economic Factors in Facelift Surgery in the USA: A Retrospective Multi-center Analysis.

Background: The demand for surgical facial rejuvenation procedures, such as facelifts, has risen in recent decades. However, limited research has addressed the epidemiological and economic aspects of these procedures. This study examines trends in facelift surgeries using data from the Healthcare Cost and Utilization Project (HCUP) National Inpatient Sample (NIS) database.

The potential association between oral lichen planus and vaccination against hepatitis B. A real-world study analyzing data from approximately 200,000 patients.

Background: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are immune-mediated conditions that may occur in response to medications or vaccines. Although hepatitis B vaccination is widely considered safe, isolated case reports have suggested a possible link to OLP/OLL. However, large-scale epidemiologic data are lacking.

Risk Factors Associated With Bell's Palsy: A Real-World Analysis of 281,600 Patients.

Introduction: Bell's palsy is the most common cause of peripheral facial paralysis, with an annual incidence of 5-50 per 100,000 cases worldwide. Its etiology remains largely unknown, though risk factors such as herpes simplex virus reactivation, diabetes, depression, and pregnancy-related complications have been suggested. Understanding these risk factors is critical for improving diagnosis, prevention, and treatment strategies.

Clinical and oncological outcome in locoregional advanced oral squamous cell carcinoma treated by primary chemoradiation.

Objective: Despite advancements in current cancer treatments, surgical resection remains to date the gold standard in the treatment of oral squamous cell carcinoma (OSCC). Primary chemoradiation (CRT), can be considered as an alternative treatment in cases of locoregional advanced diseases or patients declining surgery. The aim was to assess the clinical and oncological outcome of patients with OSCC receiving CRT.

The future role of mitochondrial drugs in vascularized composite allotransplantation: A short review.

Vascularized composite allotransplantation (VCA) has emerged as an innovative strategy to restore form and function in patients with severe tissue defects involving anatomical regions such as the face, hand, and abdominal wall. Composite allografts are composed of diverse tissues, including skin, muscle, bone, vasculature, nerves, and mucosal surfaces, posing unique challenges in immunological management. Clinical outcomes following VCA surgeries have been encouraging; however, a comprehensive understanding of the underlying cellular interactions and molecular pathways is still predominantly derived from studies in solid organ transplantation (SOT).

Cellular senescence-from solid organs to vascularized composite allotransplants.

Vascularized composite allotransplantation (VCA) has emerged as a novel therapy approach to restore form and function in patients with severe tissue defects of the face, hand, and abdominal wall, among other anatomical regions. The composite allografts comprise different tissues such as skin, muscle, or bone. Clinical data demonstrate promising mid- and long-term outcomes following VCA surgery, but our understanding of the cellular interactions and molecular pathways in VCA surgery is oftentimes deduced from solid organ transplantation (SOT).

Matrix Wave System for Mandibulo-Maxillary Fixation-Just Another Variation on the MMF Theme?-Part II: In Context to Self-Made Hybrid Erich Arch Bars and Commercial Hybrid MMF Systems-Literature Review and Analysis of Design Features.

Study Design: Trends in the utilization of Mandibulo-Maxillary Fixation (MMF) are shifting nowadays from tooth-borne devices over specialized screws to hybrid MMF devices. Hybrid MMF devices come in self-made Erich arch bar modifications and commercial hybrid MMF systems (CHMMFSs).

Objective: We survey the available technical/clinical data.

Matrix Wave System for Mandibulo-Maxillary Fixation-Just Another Variation on the MMF Theme? Part I: A Review on the Provenance, Evolution and Properties of the System.

Study Design: The advent of the Matrix Wave System (Depuy-Synthes)-a bone-anchored Mandibulo-Maxillary Fixation (MMF) System-merits closer consideration because of its peculiarities.

Objective: This study alludes to two preliminary stages in the evolution of the Matrix Wave MMF System and details its technical and functional features.

Results: The Matrix Wave System (MWS) is characterized by a smoothed square-shaped Titanium rod profile with a flexible undulating geometry distinct from the flat plate framework in Erich arch bars.

What are the functional outcomes of total laryngeal transplantation? A systematic review of preclinical and clinical studies.

Purpose: This systematic review aims to evaluate the functional outcomes of total laryngeal transplantation by synthesizing findings from both preclinical and clinical studies. It focuses on assessing postoperative functional recovery, including swallowing, airway patency, phonation, and speech, while also considering the associated morbidities and immunosuppressive strategies.

Methods: A systematic review was conducted for functional outcomes of total laryngeal transplantation through PubMed/MEDLINE, Embase, Scopus, and Web of Science databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review.

This review addresses the integration of chimeric antigen receptor (CAR)-T cell therapy with reconstructive oncologic surgery in treating peripheral solid tumors, including melanoma, sarcomas, breast cancer, and head and neck cancers. While CAR-T cells have demonstrated effectiveness in blood cancers, their efficacy in solid tumors has been limited due to tumor heterogeneity, immune suppression, and poor cellular infiltration. Emerging approaches involving localized CAR-T cell delivery, improved CAR design, and targeted antigen selection (such as HER2, MUC1, GD2, and B7-H3) are discussed as promising strategies to enhance therapeutic outcomes.

Implant-Based Chin Augmentation Vs Osseous Genioplasty: A Systematic Review of Indications and Outcomes.

Osseous genioplasty (OG) and implant-based chin augmentation are 2 primary approaches for correcting microgenia. A comprehensive synthesis comparing their outcomes, safety profiles, and patient satisfaction is lacking. In this study, the authors aim to assess the safety and outcome profile of implant-based chin augmentation and OG.

In vitro study on the osteoimmunological potential of magnesium implants (WE43MEO).

Introduction: Bioresorbable implants significantly advance orthopedics and regenerative medicine, offering advantages over permanent implants for bone regeneration. They eliminate the need for secondary surgery and reduce long-term risks associated with permanent implants. Magnesium-based alloys are particularly promising, as their biocompatibility and mechanical properties are similar to bone.

Acetylsalicylic Acid and Head and Neck Cancer: Risk, Five-Year Survival, and Recurrence in over 11,000,000 Patients-A Retrospective Case-Control Study.

: Acetylsalicylic acid (ASA) medication has been suggested to have a beneficial effect on cancer risk and survival. Therefore, this retrospective case-control study investigated the correlation between ASA and HNC in over 11,000,000 patients to investigate the impact of ASA intake on the risk of developing HNC, five-year survival rates, and the likelihood of secondary malignant neoplasms and malignant lymph node involvement. : Retrospective clinical data was retrieved from a federated EHR network.

Diagnosing facial synkinesis using artificial intelligence to advance facial palsy care.

Facial palsy (FP) can lead to significant psychological and physical burdens such as facial synkinesis. This involuntary simultaneous movement of facial musculature remains challenging to diagnose and treat. This study aimed to develop a cost-effective, rapid, and accurate artificial intelligence (AI)-based algorithm to screen FP patients for facial synkinesis.

Osseous Genioplasty and Its Impact on Airway Volume-What is the Evidence?

Osseous genioplasty (OG) improves facial aesthetics by 3-dimensionally repositioning the chin and associated soft tissues. Although its effects on airway volumes and obstructive sleep apnea (OSA) have been investigated, the available evidence remains limited. The authors of this study performed a systematic review using the databases PubMed/MEDLINE, Web of Science, Google Scholar, Cochrane, and EMBASE through January 2025.

Influence of pre-bending on primary fixation stability in one-segmental mandibular reconstruction.

Background: The fixation of osseous free flaps for segmental mandible reconstruction after resection is most commonly performed with patient-specific 3D printed or conventional load-bearing reconstruction plates. The main challenge with conventional plates is the step of manual bending to adjust the plate to the specific mandible of the patient. To date, the influence of this permanent plate deformation on the biomechanical conditions within the healing regions remains unknown.

Automated detection and classification of osteolytic lesions in panoramic radiographs using CNNs and vision transformers.

Background: Diseases underlying osteolytic lesions in jaws are characterized by the absorption of bone tissue and are often asymptomatic, delaying their diagnosis. Well-defined lesions (benign cyst-like lesions) and ill-defined lesions (osteomyelitis or malignancy) can be detected early in a panoramic radiograph (PR) by an experienced examiner, but most dentists lack appropriate training. To support dentists, this study aimed to develop and evaluate deep learning models for the detection of osteolytic lesions in PRs.

Analyzing the candidate pool for Vascularized Composite Allotransplantation - A multi-center OPTN study with a focus on face transplant candidates.

Vascularized Composite Allotransplantation (VCA) provides reconstructive options for patients with severe tissue trauma, yet multi-center analyses of VCA candidates remain scarce. This study analyzed the Organ Procurement and Transplantation Network (OPTN) database to assess the VCA candidate pool and comparatively analyzed facial VCA (fVCA) and non-fVCA to better understand their specific characteristics. The OPTN database was searched from 2008 to 2024, including all VCA types and excluding patients under 18 years or with extreme body mass indices (BMI; <7 kg/m or >250 kg/m).

A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer.

Salivary gland cancers are rare, diverse malignancies characterized by poor response to immunotherapy. The tumor immune environment in these cancers remains poorly understood. To address this, we perform an integrative analysis of the tumor immune microenvironment in a large cohort of advanced salivary gland cancer samples.

Benefit from adjuvant radiotherapy in early-stage oral cavity and oropharyngeal cancer with solitary ipsilateral lymph node metastasis - A population-based study on German cancer registry data.

Background: The benefit of adjuvant radiotherapy (RT) for patients with early-stage oral cavity squamous cell carcinoma (OSCC) or p16-negative oropharyngeal squamous cell carcinoma (OPSCC) with a solitary ipsilateral lymph node metastasis remains unclear.

Methods: A population-based analysis was conducted to assess overall survival (OS) and the incidence of locoregional recurrence (LRR) in patients diagnosed with pT1/pT2 OSCC or p16-negative OPSCC and a solitary ipsilateral lymph node metastasis without extracapsular spread (pN1) between 2017 and 2022. Information regarding clinical characteristics and outcomes was gathered from 12 clinical cancer registries in January 2024.

Towards optimized donor site closure of radial forearm flaps: A cohort study of two techniques.

The radial forearm flap (RFF) is widely used for microvascular reconstruction in the head and neck region, but donor site complications, such as flexor tendon exposure, can impact patient recovery. This study retrospectively analyzed all patients who underwent RFF surgery between April 2017 and July 2023 to identify risk factors for donor site complications and compare the efficacy of two full-thickness skin graft (FTSG) designs: semilunar and VY/Dagger shaped. A matched-pair analysis was performed, and uni- and multivariate analyses were conducted to assess complication risks.

Surgical treatment of Merkel cell carcinoma of the head and neck: Experiences from a single-center cohort.

Merkel cell carcinoma (MCC) is a rare malignancy, with about half of cases affecting the head and neck region. This retrospective study evaluated risk factors and survival outcomes in 89 patients (47 females, 42 males, median age: 77 years) treated with curative surgical therapy ± adjuvant therapy at a single center from 2010 to 2023. Most patients (71.

The prevalence and prognostic value of CD168 in early-stage oral squamous cell carcinoma.

Objective: CD168 has been established as a negative prognostic marker in various tumor entities leading to a poor prognosis. Regarding OSCC, there is a lack of comprehensive studies that examine the correlation between CD168 expression and clinical outcome, hindering the implementation of this prognostic factor into clinical practice.

Materials And Methods: This retrospective analysis included all patients with primary pT1 and pT2 pN0 OSCC who received surgical therapy without the need for adjuvant therapy (pN0, M0, R0) over a seven-year long period.