Financial Toxicity, Psychological Well-Being, and Quality of Life in Hematopoietic Stem Cell Transplantation.

Background: Financial toxicity is a well-documented consequence of cancer care and may disproportionately impact patients with hematologic malignancies due to the high cost and intensity of hematopoietic stem cell transplant (HSCT). This population is particularly vulnerable to the psychological consequences of financial toxicity; however, the longitudinal relationship between financial toxicity and psychological well-being-particularly positive psychological well-being-remains understudied.

Objective: To assess longitudinal associations between financial toxicity and patient-reported psychological distress (anxiety, depression, and post-traumatic stress disorder [PTSD] symptoms), positive psychological well-being (PPWB), coping, and quality of life (QOL) in patients with hematologic malignancies who received allogeneic HSCT.

CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review.

This review addresses the integration of chimeric antigen receptor (CAR)-T cell therapy with reconstructive oncologic surgery in treating peripheral solid tumors, including melanoma, sarcomas, breast cancer, and head and neck cancers. While CAR-T cells have demonstrated effectiveness in blood cancers, their efficacy in solid tumors has been limited due to tumor heterogeneity, immune suppression, and poor cellular infiltration. Emerging approaches involving localized CAR-T cell delivery, improved CAR design, and targeted antigen selection (such as HER2, MUC1, GD2, and B7-H3) are discussed as promising strategies to enhance therapeutic outcomes.

A Structured Peer Support Intervention for Patients With Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation: Peer Support Interventionists' Perspectives.

Background: Peer support is emerging as an important component of supportive care for patients with hematologic malignancies, but it has not been robustly implemented in patients undergoing hematopoietic stem cell transplantation (HSCT).

Objectives: This qualitative study aimed to explore the experiences of peer support interventionists (participants) delivering a structured, 5-session, phone-delivered peer support intervention, the Supporting Transplant Experiences with Peer Program (STEPP) for patients undergoing HSCT.

Methods: Adult patients who underwent allogeneic or autologous HSCT for the treatment of a hematologic malignancy within the past 3 years were eligible to volunteer in this study as trained STEPP interventionists.

VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.

Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that cancers of nervous system lineage, including adult and pediatric gliomas and neuroblastomas, required the nuclear kinase vaccinia-related kinase 1 (VRK1) for their survival in vivo. VRK1 dependency was inversely correlated with expression of its paralog VRK2.

Comparing High School Sport Specialization Trends Between Division I and Club Collegiate Athletes.

Background: Adolescent athletes report that sports specialization improves their ability to receive a collegiate athletics scholarship, though this is not well-understood. The purpose of this study was to examine self-reported trends in high school specialization and influences for sport participation between Division I (D-I) and college-aged club (club) athletes.

Hypothesis: There would be no difference in high school sport specialization or sport participation influences between D-I and club athletes.

High School Sport Specialization and Injury in Collegiate Club-Sport Athletes.

Context: Sport specialization during adolescence may affect future injury risk. This association has been demonstrated in some professional sport athletes.

Objective: To determine the association between adolescent sport specialization levels in high school and injuries sustained during collegiate club sports.

Training Load and Injury Among Middle School-Aged Athletes.

Context: Young athletes are encouraged to participate in high-intensity sport programs. However, most research on the association between training volume (TV) and injury has been performed on adult or professional athletes.

Objective: To evaluate the association between acute and chronic TV (hours/week) and reported injury (yes/no) and evaluate the relationship between acute : chronic TV and injury while controlling for sex, age, and prior injury in young athletes.

Evaluation of adolescent sport specialization and injury mechanism by sex: A secondary analysis.

Objectives: The purpose of this study was to compare the association of sport specialization with previous overuse and acute injuries between male and female adolescent athletes.

Design: Cross-sectional study.

Methods: Questionnaires were completed by adolescent athletes from various sports at sport club summer events in the state of Wisconsin.

Environmental Conditions, Preseason Fitness Levels, and Game Workload: Analysis of a Female NCAA DI National Championship Soccer Season.

Benjamin, CL, Hosokawa, Y, Curtis, RM, Schaefer, DA, Bergin, RT, Abegg, MR, and Casa, DJ. Environmental conditions, preseason fitness levels, and game workload: Analysis of a female NCAA DI National Championship Soccer Season. J Strength Cond Res 34(4): 988-994, 2020-The purpose of this study was to determine the independent and combined moderating effect of aerobic fitness and environmental conditions on physical workloads during collegiate female soccer matches.

Sport-Specific Associations of Specialization and Sex With Overuse Injury in Youth Athletes.

Background: Significant evidence has emerged that sport specialization is associated with an increased risk of overuse injury in youth athletes. Several recommendations exist to reduce the risk of overuse injury in youth sports, but the risk of overuse injuries may be dependent on specific movements required by a given sport.

Hypotheses: Associations between specialized sport participation and overuse injury will exist in volleyball athletes but not soccer or basketball athletes.

Exploring Coaches' Perceptions of Youth Sport Specialization: A Comparison of High School and Club Sport Contexts.

Context: Previous researchers have identified sport specialization as being associated with various negative outcomes (eg, overuse injuries and adverse psychosocial outcomes). However, little is known regarding how the underlying attitudes, beliefs, and values of sport stakeholders may be shaping this trend.

Objective: To examine the perceptions of coaches in the high school versus club sport setting and compare their attitudes and behaviors toward sport specialization.

A Comparison of Emergency Preparedness Between High School Coaches and Club Sport Coaches.

Context: Recent studies suggested that a large population of high school-aged athletes participate on club sport teams. Despite attempts to document emergency preparedness in high school athletics, the adherence to emergency and medical coverage standards among club sport teams is unknown.

Objective: To determine if differences in emergency preparedness and training existed between coaches of high school teams and coaches of high school-aged club teams.

A Comparison of Team Sport Volume Surveyed Between High School and Club Sport Coaches.

Background: Club sport participation is increasingly common among high school athletes. Sport participation characteristics may vary widely between the high school and club sport settings. However, there have been no large-scale comparisons of sport participation volume between high school and club teams from similar sports.

Parents' Awareness and Perceptions of Sport Specialization and Injury Prevention Recommendations.

Objective: To conduct a survey of parents to determine their knowledge of sport volume recommendations and examine their perceptions toward sport specialization.

Design: Cross-sectional survey.

Setting: Youth sport athletic tournaments, competitions, and practices.

Socioeconomic status of parents with children participating on youth club sport teams.

Objectives: To describe the socioeconomic status, measured by household income and educational attainment, of parents with children participating on youth club sport teams.

Design: Cross-sectional survey.

Setting: Local sport events.

Knowledge, Attitudes, and Beliefs of Youth Club Athletes Toward Sport Specialization and Sport Participation.

Background: There are a variety of proposed motivations for sport specialization, such as improving sport skills to an elite level, making all-star or travel teams, or receiving a scholarship or professional contract. However, there has not been a quantitative examination of the attitudes and beliefs that may be contributing to the trend of sport specialization and year-round sport participation.

Purpose: The primary aim was to describe the attitudes and beliefs of youth club sport athletes regarding sport specialization and sport participation.

Knowledge, Attitudes, and Beliefs of Youth Sports Coaches Regarding Sport Volume Recommendations and Sport Specialization.

Post, EG, Trigsted, SM, Schaefer, DA, Cadmus-Bertram, LA, Watson, AM, McGuine, TA, Brooks, MA, and Bell, DR. Knowledge, attitudes, and beliefs of youth sports coaches regarding sport volume recommendations and sport specialization. J Strength Cond Res 34(10): 2911-2919, 2020-Overuse injuries in youth athletes are becoming increasingly common, which may be a result of the prevalence of year-round specialized sport participation.

Sport Specialization Characteristics Between Rural and Suburban High School Athletes.

Background: Sport specialization has been associated with overuse injuries and is more common in larger high schools, which are often located in more urban/suburban settings. However, sport participation characteristics have not been compared between suburban and rural high schools.

Purpose/hypothesis: The purpose of this study was to examine the differences in sport participation characteristics between athletes at suburban and rural high schools.