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Bioactive peptides derived from animals have antitumor, antibacterial, antioxidant and other beneficial activities for human health. Successful application in preclinical models demonstrates the potential of animal-derived bioactive peptides to be developed into health foods and functional foods for the treatment of disease. The authors' prior studies have extensively investigated bioactive peptides, establishing a robust preparation and purification system. This review highlights optimized enzymatic hydrolysis methods that enhance peptide yield and bioactivity, combination separation methods that increase the efficiency of separating and purifying bioactive peptides, mass spectrometry methods that determine the molecular weight of bioactive peptides, their mechanisms of action and structure-activity relationships as well as the metabolic process of bioactive peptides in vivo.
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http://dx.doi.org/10.1016/j.foodchem.2025.145006 | DOI Listing |
Appl Environ Microbiol
September 2025
DGIMI, Université de Montpellier, INRAE, Montpellier, France.
is an entomopathogenic bacterium involved in a mutualistic relationship with nematodes. produces a multitude of specialized metabolites by non-ribosomal peptide synthetase (NRPS) pathways to mediate bacterium-nematode-insect interactions. PAX cyclolipopeptides are a family of NRP-type molecules whose ecological role remains poorly understood.
View Article and Find Full Text PDFExp Dermatol
September 2025
Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Lukang, Taiwan.
Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involves complex mechanisms, such as the production of reactive oxygen species (ROS) and sustained inflammatory responses. Current treatments, including topical steroids, moisturisers, and non-steroidal anti-inflammatory drugs (NSAIDs), often provide limited efficacy, primarily addressing symptoms rather than the underlying pathophysiological processes.
View Article and Find Full Text PDFAnim Sci J
September 2025
Department of Animal Science, Faculty of Agriculture, Ondokuz Mayis University, Atakum, Samsun, Türkiye.
This study aimed to evaluate the effect of some environment- and animal-based factors, such as body condition score (BCS) on 15-20 days before parturition, parity, and calving season on colostrum dry matter (DM), fat, solids-nonfat (SNF), protein, and lactose contents as well as colostrum and calf's serum immunoglobulin (IgG, IgA, and IgM), IGF-1, and lactoferrin concentrations in buffaloes. Therefore, the components of colostrum (at the first milking) and calf serum samples (at 24-48 h and 28 days after birth) from 86 Anatolian buffalo cows were analyzed by an infrared milk analyzer and ELISA test. The high BCS enhanced colostrum DM, fat, and IgG content; calf serum IgG concentration at 24-48 h, and lactoferrin at 28 days compared to low BCS.
View Article and Find Full Text PDFFood Res Int
November 2025
Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran; Institute of Leisure Agriculture, Shandong Academy of Agricultural Sciences, Jinan 250100, China. Electronic address:
Hen eggs are rich in proteins, which are a potential source of bioactive peptides. Incubation of fertilized egg changes the egg protein, which may affect the properties and activity of derived peptides. To understand these metamorphoses, hydrolysate fractions of 10-day incubated chicken embryo (CE) proteins of 0.
View Article and Find Full Text PDFFood Res Int
November 2025
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest Univer
In recent years, various drugs have been proven to effectively alleviate diabetes, but these drugs are associated with serious adverse reactions. Therefore, the development of safer and more effective new hypoglycemic drugs has become a global research focus. Plant-derived hypoglycemic peptides (PDHPs), due to their remarkable hypoglycemic activity and safety, have emerged as potential candidates for preventing and improving symptoms in diabetic patients.
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