Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In recent years, various drugs have been proven to effectively alleviate diabetes, but these drugs are associated with serious adverse reactions. Therefore, the development of safer and more effective new hypoglycemic drugs has become a global research focus. Plant-derived hypoglycemic peptides (PDHPs), due to their remarkable hypoglycemic activity and safety, have emerged as potential candidates for preventing and improving symptoms in diabetic patients. This paper reviews the latest research progress of PDHPs in terms of biological sources, preparation methods, purification, structural identification, structure-activity relationships, and activity evaluation. It also systematically summarizes and prospects the challenges faced by Artificial Intelligence (AI)-assisted PDHPs development and the future growth of PDHPs. This review not only fills the gap in comprehensive literature on PDHPs but also lays a foundation for in-depth research on PDHPs and the development of related products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.foodres.2025.117071 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A systematic review on plant-derived hypoglycemic peptides: Biological sources, preparation methods, mechanism of action and structure-activity relationships.
Food Res Int
November 2025
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest Univer
In recent years, various drugs have been proven to effectively alleviate diabetes, but these drugs are associated with serious adverse reactions. Therefore, the development of safer and more effective new hypoglycemic drugs has become a global research focus. Plant-derived hypoglycemic peptides (PDHPs), due to their remarkable hypoglycemic activity and safety, have emerged as potential candidates for preventing and improving symptoms in diabetic patients.
View Article and Find Full Text PDFTrifolium pratense-Derived Exosome Improved Serum Biochemical Parameters and Pancreatic Genes in STZ-Induced Diabetic Rats.
Endocrinol Diabetes Metab
September 2025
Fertility and Infertility Research Center, Health Technology Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Introduction: Plant-derived exosomes (PDEs) are promising nanotherapeutics for improving chronic diseases, such as diabetes mellitus. Trifolium pratense (TP) is a flowering herb with potent antioxidant and antidiabetic properties. The present study aimed to explore the diabetic-healing effects of TP-derived exosomes (TPDEs) in streptozotocin (STZ)-induced diabetic rats.
View Article and Find Full Text PDFEggplant ( spp.) Fruits Dietary Polyphenols Upregulate the Expression of Glucose Transporter Protein in Palmitate-Induced Diabetic Cell Line C2C12.
Int J Mol Sci
August 2025
Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure 340252, Nigeria.
Studies utilizing cell-based systems to investigate plant-based diets for diabetes management are gaining attention due to the adverse effects associated with commercially available drugs. However, the molecular mechanisms underlying the anti-diabetic effects of specific plant-derived products remain inadequately explored. The major aim of our study was to elucidate the molecular mechanisms by which bioactive compounds in the fruit of spp.
View Article and Find Full Text PDFFormation of Plant Derived Bioactive Peptides During Simulated Gastro-Intestinal Digestion: A Systematic Review.
Biofactors
August 2025
Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
A plant-based diet is known to be nutrient-dense and rich in fibers, healthy fats, proteins, vitamins, and minerals. A diet rich in plant-based foods may help reduce the risk of chronic diseases such as cardiovascular disease and diabetes. As consumers become more health conscious, there is a growing interest in plant-based diets.
View Article and Find Full Text PDFStructural characterization and functional evaluation of polysaccharides extracted from the heart of date palm (Phoenix dactylifera L.): Insights into α-amylase inhibition and antidiabetic potential.
Int J Biol Macromol
August 2025
University of Monastir, Faculty of Sciences of Monastir, Laboratory of Interfaces and Advanced Materials (LIMA), Bd. of the Environment, 5019 Monastir, Tunisia.
Plant-derived polysaccharides are gaining increasing attention for their diverse bioactive properties, particularly in the management of metabolic disorders such as diabetes. This study aims to isolate, characterize, and evaluate a novel polysaccharide from the heart of the date palm (Phoenix dactylifera L.), designated PHDP, for its potential antidiabetic activity.
View Article and Find Full Text PDF