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Secondary chest wall deformities are usually more complex and difficult to correct than primary deformities, especially the secondary chest wall deformity after cardiovascular surgery. This occurs because the severe adhesions in the mediastinum, the risk of bleeding, and the complexity of the deformity increase the difficulty of correcting the deformity. However, by combining the modified Wang procedure and Wenlin procedure, we can overcome these shortcomings.
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http://dx.doi.org/10.1111/ans.70210 | DOI Listing |
Contemp Clin Trials
September 2025
Weill Cornell Medicine Center for Global Health, New York, NY, USA.
Introduction: Preclinical and clinical study data show that combining bedaquiline (B or BDQ), moxifloxacin (M), and pyrazinamide (Z), known as BMZ, has potent antimicrobial activity that might shorten treatment duration for drug-susceptible pulmonary tuberculosis.
Methods/design: We describe the design of Tuberculosis Trials Consortium (TBTC) Study 38/CRUSH-TB (NCT05766267), an open-label multicenter international randomized controlled phase 2C trial that compares two four-month regimens, BMZ plus rifabutin (Rb) (2BMZRb/2BMRb) or BMZ plus delamanid (D or DLM) (2BMZD/2BMD), with standard 6-months isoniazid, rifampin, pyrazinamide, and ethambutol (HRZE). All drugs are administered seven days per week, under direct observation, at least five days per week.
Lancet Infect Dis
September 2025
The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol in drug-susceptible tuberculosis.
Methods: Clo-Fast was a phase 2c open-label trial recruiting participants at six sites in five countries.
Support Care Cancer
September 2025
Department of Palliative Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Purpose: There are no methods for assessing the need for multimodal care in cancer cachexia. We examined nine components in evaluating needs among advanced cancer patients.
Methods: This was a self-administered survey.
Perfusion
September 2025
Department of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, UK.
IntroductionWe report the successful use of erector spinae (ESP) plane block in the management of a patient with severe respiratory failure secondary to chest trauma requiring invasive ventilation and Veno-venous extracorporeal membrane oxygenation (V-V ECMO).Case reportA 64-year-old man with flail chest and severe respiratory failure required V-V ECMO. An ESP plane block on day 3 enabled extubation, mobilisation, and secretion clearance, leading to ECMO weaning after six days and discharge 18 days post-injury.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom; Newham University Hospital, Barts Health NHS Trust, London, United Kingdom. Electronic address:
Background: Myocarditis secondary to Listeria monocytogenes is rare but life-threatening.
Case Summary: A 54-year-old woman with a prior history of systemic lupus erythematous on immunosuppression presented with chest pain and fever. Troponin and C-reactive protein levels were elevated, and an electrocardiogram showed T-wave inversion.