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Objective: Urotherapy effectively treats pediatric lower urinary tract symptoms, but its delivery is limited in clinical settings. We examined the feasibility and effectiveness of Bladder Basics, a home-based, self-paced online bladder health education program, in improving symptoms and knowledge.
Methods: Children aged 5-10 years with bladder symptoms and their parents were recruited. All participants completed Bladder Basics over four weeks, with outcomes measured at baseline, 4 weeks, and 12 weeks. Feasibility was evaluated through recruitment, engagement, and post-assessment completion. Secondary outcomes included dysfunctional voiding symptom scores, parents' subjective improvement, care-seeking interest, bladder health knowledge, and self-efficacy. Analyses included paired t tests, Wilcoxon tests, sign tests, and McNemar's tests.
Results: Of 70 families, 72% completed the program, 73% completed the 4-week survey, and 67% completed the 12-week survey. Symptom scores improved significantly: 32% at 4 weeks and 42% at 12 weeks. Of children initially screening positive for bladder symptoms, 39% fell below the cutoff score at 4 weeks and 55% at 12 weeks. 85% and 93% of parents reported child symptom improvements at 4 and 12 weeks. Parents reporting no need for clinic visits increased from 45% to 69% at 4 weeks. Knowledge of key urotherapy concepts was improved, such as peeing every 3 hours and bowel health awareness. Self-efficacy improved significantly, with a median increase of 4.6 points at 4 weeks (p = 0.018).
Conclusion: Bladder Basics improved bladder symptoms and knowledge and demonstrated potential for broader scalability with strong participant interest and high engagement.
Clinical Trial Registration Number: NCT05852353.
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http://dx.doi.org/10.1016/j.urology.2025.05.058 | DOI Listing |
Front Oncol
August 2025
Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.
Purpose: Bladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA. However, a stroma-relevant biomarker for predicting BLCA progression is still lacking.
View Article and Find Full Text PDFNatl Sci Rev
August 2025
Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Multimodal phototheranostics has been recognized as one of the most momentous advances in cancer treatment. Of particular interest is a single molecular species simultaneously featuring in multiple imaging and synergistic phototherapies; the development of such a molecular species is nevertheless a formidably challenging task. Herein, we innovatively designed and synthesized three aggregation-induced emission (AIE)-active molecules with emission in the second near-infrared (NIR-II) window, by employing 10-indeno[1,2-][1,2,5]thiadiazolo[3,4-]quinoxalin-10-one as the electron acceptor, 4-(-butyl)--(4-(-butyl)phenyl)--phenylaniline as the electron donor, and different π-bridge moieties.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Background: Bladder cancer (BLCA) is a prevalent malignancy with substantial consequences for patient health. This study aimed to elucidate the underlying mechanisms of BLCA through integrated multi-omics analysis.
Methods: Tumor and adjacent tissues from BLCA patients underwent transcriptomic, whole-exome sequencing, metabolomic, and intratumoral microbiome analyses.
Cell Calcium
August 2025
Department of Urology, The First People's Hospital of Yunnan Province, Kunming, 650032, Yunnan, China; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, Yunnan, China. Electronic address:
Background: Prostate cancer remains a leading cause of cancer-related deaths in men, with radioresistance limiting treatment efficacy. This study investigates the role of Calbindin 1 (CALB1), a calcium-binding protein regulated by miR-186-5p, in prostate cancer progression and radiation response.
Methods: CALB1 expression was analyzed using GEO and TCGA datasets, and the regulatory relationship with miR-186-5p was validated.
Can Urol Assoc J
August 2025
Urologic Oncology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Introduction: Approximately 25% of patients diagnosed with bladder cancer have muscle-invasive disease (MIBC). While real-world data have highlighted opportunities to improve curative-intent treatment rates, comprehensive population-level data in Canada are limited. This study aimed to assess patterns of care and outcomes in a real-world cohort of MIBC in Canada.
View Article and Find Full Text PDF