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The study revealed that the serum DPs concentrations in thyroid patients ranged from 2.45 to 141.25 ng/g lw, with the female group showing higher DPs concentrations and a higher f value than males. Younger participants exhibited had higher serum DPs concentrations and f values compared to older age groups, compared to middle-aged and elderly groups, indicating a tendency for anti-DP accumulation. In addition, the f value was found to be lower in patients with metastatic thyroid tumor, potentially due to an enhanced capacity to metabolize anti-DP post-metastasis. We also examined the population of patients with varying diameters. Consequently, future studies should further investigate the possible relationship between DPs and thyroid function, with an emphasis on anti-DP.
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http://dx.doi.org/10.1016/j.ecoenv.2025.118410 | DOI Listing |
BMC Oral Health
August 2025
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Various medicaments have been utilized as an aid for wound healing following vital pulp treatment. Many of them are synthetic in origin and have disadvantages as limited amount of cytotoxicity and great expense. Hence, to tackle these drawbacks, naturally derived blended scaffolds have been employed in renovative dental field.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Department of Physics, Xiamen University, Xiamen 361005, China.
Cr-doped lead-free halide double perovskites (DPs) have recently emerged as promising near-infrared (NIR) phosphors, owing to their tunable optical properties. Herein, we report a Cr-doped CsAgNaInBiCl system exhibiting dual-band luminescence under 405 nm excitation and NIR-only luminescence under 808 nm excitation. Increasing Cr concentration induces a redshift and attenuation in self-trapped excitons (STEs) luminescence, while Cr luminescence first increases and then decreases.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
November 2025
Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Udupi, Karnataka, India.
Context: Therapeutic drug monitoring (TDM) involves the collection of biological samples such as blood, plasma, urine, and saliva. The most commonly used biological matrix for the detection of drugs is either blood or plasma, as they are widely accepted by the regulatory authorities. Such studies require a significant amount of blood to be collected and even more if the study is performed in a plasma sample.
View Article and Find Full Text PDFJ Pharm Sci
July 2025
Sterile Product and Device Development, Bristol Myers Squibb, 1 Squibb Drive, 08901 NJ, United States.
High dose biologic drug products (DPs) have become a common trend for the treatment of chronic diseases across a wide range of therapeutic areas. While the expectation is to deliver these DPs via subcutaneous (SC) self-administration due to patient and healthcare provider preference, there are unique challenges that make the product development highly complex. Critical aspects that need to be considered while designing the development roadmap include high concentration formulation development, drug-device combination product design to deliver large volumes, assessment of pharmacokinetic (PK) bridging risk, user preferences, patient tolerability, etc.
View Article and Find Full Text PDFACS Macro Lett
August 2025
Department of Physics, Hong Kong University of Science and Technology, Hong Kong, China.
We report on the desorption process of polystyrene (PS) from its host, an adsorbed layer on oxide-covered silicon, at a moderate temperature of 120 °C. Measurements were conducted on deuterated polystyrene (-PS) adsorbed on SiO beneath layers of hydrogenated PS of varying thicknesses (). To assess the desorption dynamics, we measured the width of the broadening -PS profile (σ) and the concentration of -PS on the sample surface after 20 days of annealing.
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