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Many components of the Earth system feature self-reinforcing feedback processes that can potentially scale up a small initial change to a fundamental state change of the underlying system in a sometimes abrupt or irreversible manner beyond a critical threshold. Such tipping points can be found across a wide range of spatial and temporal scales and are expressed in very different observable variables. For example, early-warning signals of approaching critical transitions may manifest in localised spatial pattern formation of vegetation within years as observed for the Amazon rainforest. In contrast, the susceptibility of ice sheets to tipping dynamics can unfold at basin to sub-continental scales, over centuries to even millennia. Accordingly, to improve the understanding of the underlying processes, to capture present-day system states and to monitor early-warning signals, tipping point science relies on diverse data products. To that end, Earth observation has proven indispensable as it provides a broad range of data products with varying spatio-temporal scales and resolutions. Here we review the observable characteristics of selected potential climate tipping systems associated with the multiple stages of a tipping process: This includes i) gaining system and process understanding, ii) detecting early-warning signals for resilience loss when approaching potential tipping points and iii) monitoring progressing tipping dynamics across scales in space and time. By assessing how well the observational requirements are met by the Essential Climate Variables (ECVs) defined by the Global Climate Observing System (GCOS), we identify gaps in the portfolio and what is needed to better characterise potential candidate tipping elements. Gaps have been identified for the Amazon forest system (vegetation water content), permafrost (ground subsidence), Atlantic Meridional Overturning Circulation, AMOC (section mass, heat and fresh water transports and freshwater input from ice sheet edges) and ice sheets (e.g. surface melt). For many of the ECVs, issues in specifications have been identified. Of main concern are spatial resolution and missing variables, calling for an update of the ECVS or a separate, dedicated catalogue of tipping variables.
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http://dx.doi.org/10.1007/s10712-024-09866-4 | DOI Listing |
Front Microbiol
August 2025
College of Life Sciences, Hebei University, Baoding, China.
Introduction: The Zika virus (ZIKV) envelope (E) protein is critical for viral replication and host interactions. Although glycosylation of the E protein is known to influence viral infectivity and immune evasion, the specific functional roles of E protein glycosylation in ZIKV infectivity in mosquito cells remain unclear.
Methods: In this study, we generated a deglycosylation mutant ZIKV with a T156I substitution in the E protein and investigated its effects on viral replication and viral-host interactions in mosquito C6/36 cells.
Signal Transduct Target Ther
September 2025
Beijing Key Laboratory of Surveillance, Early Warning and Pathogen Research on Emerging Infectious Diseases, Beijing Research Center for Respiratory Infectious Diseases, Public Health Emergency Management Innovation Center, Beijing Center for Disease Prevention and Control, Beijing, China. wangqy@bj
In November 2024, there was an unusual surge in human metapneumovirus (hMPV) infection cases in Beijing. We performed an epidemiological investigation among cases with acute respiratory tract infection (ARTI). We enrolled ARTI cases from 35 sentinel hospitals, collected samples and medical records, conducted comprehensive pathogen testing, sequenced target genes or whole genomes, and performed phylogenetic analysis.
View Article and Find Full Text PDFPLoS One
September 2025
CIRAD, UMR ASTRE, Montpellier, France.
Since the 2013-2014 Ebola virus disease outbreak, Guinea has faced recurrent epidemics of viral hemorrhagic fevers. Although the country has learned from these epidemics by improving its disease surveillance and investigation capacities, local authorities and stakeholders, including community actors, are not sufficiently involved in the disease-emergence response. As a result, measures are not fully understood and have failed to engage local stakeholders.
View Article and Find Full Text PDFBiosaf Health
August 2025
NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
The epidemiological characteristics of emerging infectious disease outbreaks in recent years have underscored the critical importance of controlling imported infectious diseases. In this study, we implemented dynamic tracking of microbial invasions by monitoring environmental microbes at the customs and ports. From July to September 2024, a total of 126 environmental samples were collected from three ports of entry in Shenzhen, China.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
College of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China. Electronic address:
Background: Aflatoxin B1 (AFB1) is a highly carcinogenic mycotoxin frequently found in contaminated food products, posing a significant threat to public health and food safety. Therefore, the development of rapid, sensitive, and reliable detection methods for AFB1 is critical for early warning and prevention. However, traditional detection techniques often require expensive equipment, skilled personnel, and complex procedures, limiting their suitability for on-site applications.
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