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Introduction: Currently, percutaneous nephrolithotomy (PCNL) is a first-line treatment method for large and staghorn kidney stones. Predicting the efficiency of the performed surgical procedure is relevant at the stage of preoperative counseling of patients.
Aim: To develop a universal nomogram for predicting the efficiency of mini-PCNL taking into account the baseline characteristics and features of the patient.
Materials And Methods: A total of 251 patients with kidney stones who underwent mini-PCNL in the prone position according to the standard method through a single access were included in the study. The preoperative characteristics of patients and their impact on the outcome were evaluated. An achievement of the stone-free rate (SFR) was assessed by the computed tomography (CT).
Results: The analysis revealed factors significantly influencing the achievement of the SFR, such as stone volume >1.39 cm3 (p=0.001), stone area >189.03 mm2 (p=0.001), distance from the lowest point of the Th12 to the lower part of the lower pole calyx (T12-LP) <85.81 mm (p=0.050), distances from the lower calyx to the most cranial part of the iliac crest (ICLP) >49.1 mm (p=0.029), stone size >18.2 mm (p=0.001), number of involved calyxes >3 (p=0.001), number of involved calyxes for staghorn stones >4 (p=0.001), and staghorn stone (p=0.001). Correlation, logistic regression, and ROC analysis were performed for these factors. The area under the curve (AUC) was 0.897. A nomogram has been developed. The sensitivity of the model is 94.4%, specificity is 59.2%, and overall accuracy is 84.4%. A certificate of state registration of a computer program in the IBM SPSS Statistics syntax language "A model for predicting the SFR of mini-PCNL in patients with kidney stones" was obtained.
Conclusion: The nomogram developed on the basis of our data showed a high predictive ability in relation to the SFR with sensitivity of 94%. This nomogram is easy to use and interpret, which makes it convenient for routine practice, however, external validation is necessary to objectify the predictive ability.
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Stroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
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Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Physics and Electronic Engineering, Harbin Normal University, Harbin 150025, China.
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September 2025
Dipartimento di Chimica, Università di Pavia, Via Taramelli 12, Pavia 27100, Italy.
Machine learning (ML) and deep learning (DL) methodologies have significantly advanced drug discovery and design in several aspects. Additionally, the integration of structure-based data has proven to successfully support and improve the models' predictions. Indeed, we previously demonstrated that combining molecular dynamics (MD)-derived descriptors with ML models allows to effectively classify kinase ligands as allosteric or orthosteric.
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Community Medicine Education Promotion Office, Faculty of Medicine, Kagawa University Ikenobe, 1750-1, Miki-Cho, Kagawa, 761-0793, Japan.
Generative artificial intelligence (AI) is rapidly transforming perioperative medicine, particularly anesthesiology, by enabling novel applications, such as real-time data synthesis, individualized risk prediction, and automated documentation. These capabilities enhance clinical decision-making, patient communication, and workflow efficiency in the operating room. In education, generative AI offers immersive simulations and tailored learning experiences that improve both technical skills and professional judgment.
View Article and Find Full Text PDFTheor Appl Genet
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Institute for Breeding Research on Agricultural Crops, Julius Kühn Institute (JKI) - Federal Research Centre for Cultivated Plants, Sanitz, 18190, Germany.
Low-cost and high-throughput RNA sequencing data for barley RILs achieved GP performance comparable to or better than traditional SNP array datasets when combined with parental whole-genome sequencing SNP data. The field of genomic selection (GS) is advancing rapidly on many fronts including the utilization of multi-omics datasets with the goal of increasing prediction ability and becoming an integral part of an increasing number of breeding programs ensuring future food security. In this study, we used RNA sequencing (RNA-Seq) data to perform genomic prediction (GP) on three related barley RIL populations.
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