Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In recent years, monoelemental 2D materials (Xenes) such as graphene, graphdiyne, silicene, phosphorene, and tellurene, have gained significant traction in biosensing applications. Owing to their ultra-thin layered structure, exceptionally high specific surface area, unique surface electronic properties, excellent mechanical strength, flexibility, and other distinctive features, Xenes are recognized for their potential as materials with low detection limits, high speed, and exceptional flexibility in biosensing applications. In this review, the unique properties of Xenes, their synthesis, and recent theoretical and experimental advances in applications related to biosensing, including DNA/RNA biosensors, protein biosensors, small molecule biosensors, cell, and ion biosensors are comprehensively summarized. Finally, the challenges and prospects of this emerging field are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140353 | PMC |
| http://dx.doi.org/10.1002/advs.202500752 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peptide-Programmable DNAzyme Converter for Artificial Autocatalytic Gene Regulation.
J Am Chem Soc
September 2025
College of Chemistry and Molecular Sciences, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430072, P. R. China.
The in-depth integration of gene regulation with protein modulation can enhance cellular information processing, yet it is significantly constrained by ineffective and complex protein-to-gene transduction strategies. Herein, we developed a simple protease-guided autocatalytic gene silencing platform named iPAD (intelligent peptide-programmed deoxyribonuclease) that converts the protease recognition events into versatile DNA readout signals by rationally designing a native protease-responsive cationic peptide (PP) to efficiently modulate the DNAzyme (Dz) activity. Without requiring additional chemical modifications, the multifunctional PP regulator consists simply of one cell-specific targeting peptide segment and two cationic peptide segments isolated by one protease-specific peptide substrate.
View Article and Find Full Text PDFSystemic Delivery of an mRNA-Encoding, Tumor-Activated Interleukin-12 Lock to Eliminate Tumors and Avoid Immune-Related Adverse Events.
Nano Lett
September 2025
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China.
Interleukin-12 (IL-12) is a robust proinflammatory cytokine that activates immune cells, such as T cells and natural killer cells, to induce antitumor immunity. However, the clinical application of recombinant IL-12 has been limited by systemic immune-related adverse events (irAEs) and rapid degradation. To address these challenges, we employed mRNA technology to encode a tumor-activated IL-12 "lock" fusion protein that offers both therapeutic efficacy and systemic safety.
View Article and Find Full Text PDFBiomineralized Electroactive Microbe as the Whole-Cell Electrical Transducer for Electrochemically Online Monitoring of Lactic Acid Fermentation.
Anal Chem
September 2025
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, P. R. China.
Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (EET). Ongoing research aims to overcome current limitations and fully harness the potential of EABs for high-performance biosensing applications. Herein, we report the fabrication of an electrochemical microsensor based on biomineralized electroactive bacteria, specifically MR-1.
View Article and Find Full Text PDFParylene-coated platinum nanowire electrodes for biomolecular sensing applications.
Beilstein J Nanotechnol
August 2025
Department of Physics & Engineering Physics, Morgan State University, Baltimore, MD 21251, USA.
Nanoscale biosensors have gained attention in recent years due to their unique characteristics and size. Manufacturing steps, cost, and other shortcomings limit the widespread use and commercialization of nanoscale electrodes. In this work, a nano-size electrode fabricated by directed electrochemical nanowire assembly and parylene-C insulation is introduced.
View Article and Find Full Text PDFHybrid ZrO₂@CNTs nanocomposite electrodes for ultra-sensitive glucose detection via electrochemical biosensing.
Mikrochim Acta
September 2025
Faculty of Science, Shenyang University of Chemical Technology, Shenyang, 110142, China.
A sensitive electrochemical glucose biosensor using ZrO₂@CNTs nanocomposite was developed for real-time metabolism monitoring for athletes. The nanocomposite was prepared by a simple ultrasound-assisted technique, and the glucose oxidase (GOx) was covalently immobilized to improve the biorecognition ability. CNTs treated with acid served as a highly conductive framework, and ZrO₂ nanoparticles can provide structural stability and catalytic performance, thus showing synergistic enhancement of electron transfer kinetics and enzyme loading capacity.
View Article and Find Full Text PDF