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The efficiency optimization methods for natural coagulants are often restricted due to non-scientific trial-and-error approaches. They are inaccurate in predicting the complex interactions of jet mixing parameters, coagulant dosage, and environmental conditions. To overcome these obstacles, this research paper proposes advanced hybrid models in machine learning to enhance flocculation efficiency. We use the CatBoost model with the NTK to learn the intricate nonlinear interactions among jet velocity, mixing time, coagulant dose, pH, and turbidity. CatBoost is effective for dealing with categorical data like diverse coagulants. Meanwhile, NTK boosts the model's generalization capability, especially when the sample size becomes small or experimental datasets are applied. Lastly, SOMs and MARS are used to identify pattern recognitions in tracing the crucial interaction among mixing parameters. Reinforcement learning techniques-that include DDPG and SAC for dynamic optimization of jet velocity, mixing time, and coagulant dosage-optimize the model in real time. Utilizing NAS and Hyperband to automate model tuning, the timestamp was reduced by 40%. The proposed models heavily improve the efficiency of the flocculation process by 20-25% and allow for a good predictive accuracy of 95-97%. Paramount, however, is that the model has interpretability properties assured by SHAP and counterfactual explanations, which would give actionable insights into the most influencing factors on the efficiency of flocculation. This work represents a substantial advancement for the discipline since it introduces robust, interpretable, and real-time optimization methods to offer a practical tool through which improvement of water treatment processes would be made both sustainable and efficient.
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http://dx.doi.org/10.1038/s41598-025-96750-9 | DOI Listing |
Food Sci Biotechnol
October 2025
Department of Biotechnology, Yonsei University, Seoul, 03722 Republic of Korea.
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View Article and Find Full Text PDFJ Enzyme Inhib Med Chem
December 2025
School of Life Sciences, Jinggangshan University, Ji'an, China.
Current antithrombotic therapies face dual constraints of bleeding complications and monitoring requirements. Although natural hirudin provides targeted thrombin inhibition, its clinical adoption is hindered by sourcing limitations. This study developed a recombinant hirudin variant HMg (rHMg) with enhanced anticoagulant activity through genetic engineering and established cost-effective large-scale production methods.
View Article and Find Full Text PDFPestic Biochem Physiol
November 2025
Newcastle University, School of Natural and Environmental Sciences, Newcastle upon Tyne, UK NE1 7RU. Electronic address:
RNA interference (RNAi) is an endogenous eukaryote viral defence mechanism representing a unique form of post-transcriptional gene silencing that can be induced via the exongenous application of dsRNA. Due to its high specificity, dsRNA-based biopesticides are being developed to control pest insects. Whilst many lepidopteran species are recalcitrant to RNAi, Tuta absoluta, a polyphagous insect responsible for extensive crop damage, is sensitive.
View Article and Find Full Text PDFInt J Cancer
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Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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View Article and Find Full Text PDFMol Plant Pathol
September 2025
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
During oxidative phosphorylation, the leaked electrons generate superoxide anions to attack the mitochondrial inner membrane and impair mitochondrial activity. Three superoxide dismutases (SODs) are secreted to degrade host superoxide anions in Verticillium dahliae. However, the roles of mitochondrial SODs (mtSODs) in superoxide anion detoxification and in virulence are unknown in this fungus.
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